Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface
Through the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses. Additional non-immunological functions include the heterotypic association of class I molecules with cell...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Immunology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255522000063 |
| _version_ | 1811184604053241856 |
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| author | Fernando M. Ruggiero Sebastian Springer |
| author_facet | Fernando M. Ruggiero Sebastian Springer |
| author_sort | Fernando M. Ruggiero |
| collection | DOAJ |
| description | Through the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses. Additional non-immunological functions include the heterotypic association of class I molecules with cell surface receptors, regulating their activities by unknown mechanisms. Also, homotypic associations resulting in class I dimers and oligomers - of unknown function - have been related to pathological outcomes. In this review, we provide an overview of the current knowledge about the occurrence, biochemical nature, and dynamics of homotypic and heterotypic associations of class I molecules at the cell surface with special focus on the molecular species that take part in the complexes and on the evidence that supports novel biological roles for class I molecules. We show that both heterotypic and homotypic class I associations reported in the literature describe not one but several kinds of oligomers with distinctive stoichiometry and biochemical properties. |
| first_indexed | 2024-04-11T13:15:08Z |
| format | Article |
| id | doaj.art-bb58fe4efb714f01bbc5c191928772cc |
| institution | Directory Open Access Journal |
| issn | 2590-2555 |
| language | English |
| last_indexed | 2024-04-11T13:15:08Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Immunology |
| spelling | doaj.art-bb58fe4efb714f01bbc5c191928772cc2022-12-22T04:22:26ZengElsevierCurrent Research in Immunology2590-25552022-01-0138599Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surfaceFernando M. Ruggiero0Sebastian Springer1School of Science, Jacobs University Bremen, Campus Ring 1, D-28759, Bremen, GermanyCorresponding author.; School of Science, Jacobs University Bremen, Campus Ring 1, D-28759, Bremen, GermanyThrough the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses. Additional non-immunological functions include the heterotypic association of class I molecules with cell surface receptors, regulating their activities by unknown mechanisms. Also, homotypic associations resulting in class I dimers and oligomers - of unknown function - have been related to pathological outcomes. In this review, we provide an overview of the current knowledge about the occurrence, biochemical nature, and dynamics of homotypic and heterotypic associations of class I molecules at the cell surface with special focus on the molecular species that take part in the complexes and on the evidence that supports novel biological roles for class I molecules. We show that both heterotypic and homotypic class I associations reported in the literature describe not one but several kinds of oligomers with distinctive stoichiometry and biochemical properties.http://www.sciencedirect.com/science/article/pii/S2590255522000063MHC class IDimersOligomersFree heavy chainHomotypic associationsHeterotypic associations |
| spellingShingle | Fernando M. Ruggiero Sebastian Springer Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface Current Research in Immunology MHC class I Dimers Oligomers Free heavy chain Homotypic associations Heterotypic associations |
| title | Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface |
| title_full | Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface |
| title_fullStr | Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface |
| title_full_unstemmed | Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface |
| title_short | Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface |
| title_sort | homotypic and heterotypic in cis associations of mhc class i molecules at the cell surface |
| topic | MHC class I Dimers Oligomers Free heavy chain Homotypic associations Heterotypic associations |
| url | http://www.sciencedirect.com/science/article/pii/S2590255522000063 |
| work_keys_str_mv | AT fernandomruggiero homotypicandheterotypicincisassociationsofmhcclassimoleculesatthecellsurface AT sebastianspringer homotypicandheterotypicincisassociationsofmhcclassimoleculesatthecellsurface |