Hidden Microatelectases Increase Vulnerability to Ventilation-Induced Lung Injury

Hidden Microatelectases Increase Vulnerability to Ventilation-Induced Lung Injury

Mechanical ventilation of lungs suffering from microatelectases may trigger the development of acute lung injury (ALI). Direct lung injury by bleomycin results in surfactant dysfunction and microatelectases at day 1 while tissue elastance and oxygenation remain normal. Computational simulations of a...

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Bibliographic Details
Main Authors: Karolin Albert, Jeanne-Marie Krischer, Alexander Pfaffenroth, Sabrina Wilde, Elena Lopez-Rodriguez, Armin Braun, Bradford J. Smith, Lars Knudsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
microatelectases
alveolar interdependence
ventilation-induced lung injury
surfactant
blood-gas barrier
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.530485/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.530485/full

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