CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY
Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs in sepsis patients. Ironically this entity can increases the mortality rate. Importantly, the clinical presentations of this entity is vary ranging from malaise to coma condition. The central nervous s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2019-05-01
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| Series: | Malang Neurology Journal |
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| Online Access: | https://mnj.ub.ac.id/index.php/mnj/article/view/277 |
| _version_ | 1819017551289516032 |
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| author | Ayu Trisnawati Badrul Munir |
| author_facet | Ayu Trisnawati Badrul Munir |
| author_sort | Ayu Trisnawati |
| collection | DOAJ |
| description | Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs in sepsis patients. Ironically this entity can increases the mortality rate. Importantly, the clinical presentations of this entity is vary ranging from malaise to coma condition. The central nervous system is susceptible to damage that caused by systemic inflammation including sepsis with complex pathophysiologies such as endothelial dysfunction, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction and apoptosis. In general, current management of SAE is similar with the management of sepsis incidence which includes infections management, maintaining tissue perfusion and symptomatic therapy to treat delirium and convulsions that may occur. Also, several studies continue to be developed including the use of corticosteroids, magnesium, antioxidants, and immunoglobulin. Early identification and appropriate initial handling significantly affect the output of the SAE patients. |
| first_indexed | 2024-12-21T03:05:19Z |
| format | Article |
| id | doaj.art-bb5bb8f8fa534c49afb392307280798c |
| institution | Directory Open Access Journal |
| issn | 2407-6724 2442-5001 |
| language | English |
| last_indexed | 2024-12-21T03:05:19Z |
| publishDate | 2019-05-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Malang Neurology Journal |
| spelling | doaj.art-bb5bb8f8fa534c49afb392307280798c2022-12-21T19:18:07ZengUniversity of BrawijayaMalang Neurology Journal2407-67242442-50012019-05-01529810410.21776/ub.mnj.2019.005.02.1099CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHYAyu Trisnawati0Badrul Munir1Department of Neurology Faculty of Medicine Brawijaya University, MalangDepartment of Neurology Faculty of Medicine Brawijaya University, MalangSeptic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs in sepsis patients. Ironically this entity can increases the mortality rate. Importantly, the clinical presentations of this entity is vary ranging from malaise to coma condition. The central nervous system is susceptible to damage that caused by systemic inflammation including sepsis with complex pathophysiologies such as endothelial dysfunction, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction and apoptosis. In general, current management of SAE is similar with the management of sepsis incidence which includes infections management, maintaining tissue perfusion and symptomatic therapy to treat delirium and convulsions that may occur. Also, several studies continue to be developed including the use of corticosteroids, magnesium, antioxidants, and immunoglobulin. Early identification and appropriate initial handling significantly affect the output of the SAE patients.https://mnj.ub.ac.id/index.php/mnj/article/view/277Sepsis Associated Encephalopathyseptic conditionbrain in sepsis |
| spellingShingle | Ayu Trisnawati Badrul Munir CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY Malang Neurology Journal Sepsis Associated Encephalopathy septic condition brain in sepsis |
| title | CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY |
| title_full | CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY |
| title_fullStr | CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY |
| title_full_unstemmed | CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY |
| title_short | CLINICAL APPROACH AND GUIDELINES FOR MANAGEMENT OF SEPSIS ASSOCIATED ENCEPHALOPATHY |
| title_sort | clinical approach and guidelines for management of sepsis associated encephalopathy |
| topic | Sepsis Associated Encephalopathy septic condition brain in sepsis |
| url | https://mnj.ub.ac.id/index.php/mnj/article/view/277 |
| work_keys_str_mv | AT ayutrisnawati clinicalapproachandguidelinesformanagementofsepsisassociatedencephalopathy AT badrulmunir clinicalapproachandguidelinesformanagementofsepsisassociatedencephalopathy |