AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

Abstract Background The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via an impact on cell migration. Consequently, we tested the hypothesis that...

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Bibliographic Details
Main Authors: Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters, Michael Adamzik
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Translational Medicine
Subjects:
Severe Sepsis
Jurkat Cell
Neutrophil Migration
AQP5 Expression
Immune Cell Migration
Online Access:http://link.springer.com/article/10.1186/s12967-016-1079-2

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