In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

Context Shengmai injection (SMI) has been used to treat heart failure.Objective This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).Materials and methods In vivo, DOX (15 mg/kg) was intraperitoneally injected in model, Dex (dexrazoxane), SMI-L (2....

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Bibliographic Details
Main Authors: Peng Zhou, Ge Gao, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, Shu-shu Wang, Rui Song, Hui Shi, Liang Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
Nrf2/Keap1 signal pathway
apoptosis
oxidative
DOX
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2046801

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