Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications
Mesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple biological effects and have shown promising therapeutic effects in a broad range of diseases. In order to fulfill their clinical applications in context of precision medicine, however, more detailed molecular charac...
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| Format: | Article |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.716907/full |
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| author | Juan Zhang Juan Zhang Mingzhuang Chen Mingzhuang Chen Mingzhuang Chen Jinqi Liao Chongfei Chang Yuqing Liu Arshad Ahmed Padhiar Arshad Ahmed Padhiar Yan Zhou Guangqian Zhou Guangqian Zhou Guangqian Zhou |
| author_facet | Juan Zhang Juan Zhang Mingzhuang Chen Mingzhuang Chen Mingzhuang Chen Jinqi Liao Chongfei Chang Yuqing Liu Arshad Ahmed Padhiar Arshad Ahmed Padhiar Yan Zhou Guangqian Zhou Guangqian Zhou Guangqian Zhou |
| author_sort | Juan Zhang |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple biological effects and have shown promising therapeutic effects in a broad range of diseases. In order to fulfill their clinical applications in context of precision medicine, however, more detailed molecular characterization of diverse subgroups and standardized scalable production of certain functional subgroups would be highly desired. Thus far, the generation of induced pluripotent stem cell (iPSC)-derived MSC (iMSC) seems to provide the unique opportunity to solve most obstacles that currently exist to prevent the broad application of MSC as an advanced medicinal product. The features of iMSC include their single cell clone origins, and defined and controllable cultural conditions for their derivation and proliferation. Still, comprehensive research of the molecular and functional heterogeneity of iMSC, just like MSC from any other tissue types, would be required. Furthered on previous efforts on iMSC differentiation and expansion platform and transcriptomic studies, advantages of single cell multi-omics analysis and other up-to-dated technologies would be taken in order to elucidate the molecular origin and regulation of heterogeneity and to obtain iMSC subgroups homogeneous enough for particular clinical conditions. In this perspective, the current obstacles in MSC applications, the advantages of iMSC over MSC and their implications for biological research and clinical applications will be discussed. |
| first_indexed | 2024-12-24T04:09:11Z |
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| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-24T04:09:11Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-bb5e8d5fecef40a390890063160f62592022-12-21T17:16:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.716907716907Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical ApplicationsJuan Zhang0Juan Zhang1Mingzhuang Chen2Mingzhuang Chen3Mingzhuang Chen4Jinqi Liao5Chongfei Chang6Yuqing Liu7Arshad Ahmed Padhiar8Arshad Ahmed Padhiar9Yan Zhou10Guangqian Zhou11Guangqian Zhou12Guangqian Zhou13Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Shenzhen University, Shenzhen, ChinaGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, ChinaGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Shenzhen University, Shenzhen, ChinaGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, ChinaShenzhen University General Hospital, Shenzhen, ChinaSenotherapeutics Ltd., Hangzhou, ChinaCheerland Danlun Biopharma Co., Ltd., Shenzhen, ChinaCheerland Danlun Biopharma Co., Ltd., Shenzhen, ChinaSenotherapeutics Ltd., Hangzhou, ChinaLungene Biotech Ltd., Shenzhen, ChinaLungene Biotech Ltd., Shenzhen, ChinaGuangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, Health Science Center, Shenzhen University, Shenzhen, ChinaSenotherapeutics Ltd., Hangzhou, ChinaCentral Laboratory, Longgang District People’s Hospital of Shenzhen and The Third Affiliated Hospital (Provisional) of The Chinese University of Hong Kong, Shenzhen, ChinaMesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple biological effects and have shown promising therapeutic effects in a broad range of diseases. In order to fulfill their clinical applications in context of precision medicine, however, more detailed molecular characterization of diverse subgroups and standardized scalable production of certain functional subgroups would be highly desired. Thus far, the generation of induced pluripotent stem cell (iPSC)-derived MSC (iMSC) seems to provide the unique opportunity to solve most obstacles that currently exist to prevent the broad application of MSC as an advanced medicinal product. The features of iMSC include their single cell clone origins, and defined and controllable cultural conditions for their derivation and proliferation. Still, comprehensive research of the molecular and functional heterogeneity of iMSC, just like MSC from any other tissue types, would be required. Furthered on previous efforts on iMSC differentiation and expansion platform and transcriptomic studies, advantages of single cell multi-omics analysis and other up-to-dated technologies would be taken in order to elucidate the molecular origin and regulation of heterogeneity and to obtain iMSC subgroups homogeneous enough for particular clinical conditions. In this perspective, the current obstacles in MSC applications, the advantages of iMSC over MSC and their implications for biological research and clinical applications will be discussed.https://www.frontiersin.org/articles/10.3389/fcell.2021.716907/fullmesenchymal stem cells (MSCs)induced pluripotent stem cells (iPSCs)iPSC-derived MSCs (iMSCs)heterogeneityfunctional subpopulationssingle cell transcriptomics |
| spellingShingle | Juan Zhang Juan Zhang Mingzhuang Chen Mingzhuang Chen Mingzhuang Chen Jinqi Liao Chongfei Chang Yuqing Liu Arshad Ahmed Padhiar Arshad Ahmed Padhiar Yan Zhou Guangqian Zhou Guangqian Zhou Guangqian Zhou Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications Frontiers in Cell and Developmental Biology mesenchymal stem cells (MSCs) induced pluripotent stem cells (iPSCs) iPSC-derived MSCs (iMSCs) heterogeneity functional subpopulations single cell transcriptomics |
| title | Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications |
| title_full | Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications |
| title_fullStr | Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications |
| title_full_unstemmed | Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications |
| title_short | Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications |
| title_sort | induced pluripotent stem cell derived mesenchymal stem cells hold lower heterogeneity and great promise in biological research and clinical applications |
| topic | mesenchymal stem cells (MSCs) induced pluripotent stem cells (iPSCs) iPSC-derived MSCs (iMSCs) heterogeneity functional subpopulations single cell transcriptomics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.716907/full |
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