Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states
Abstract Background To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries in different glucose metabolic states. Methods A total of 681 patients who underwent coronary angiography between...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-02080-3 |
| _version_ | 1827382428837085184 |
|---|---|
| author | Junwei Zhu Minghui Niu Chenxing Wang Ying Liang Rong Guo Fei He |
| author_facet | Junwei Zhu Minghui Niu Chenxing Wang Ying Liang Rong Guo Fei He |
| author_sort | Junwei Zhu |
| collection | DOAJ |
| description | Abstract Background To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries in different glucose metabolic states. Methods A total of 681 patients who underwent coronary angiography between January 2020 and December 2021 to determine the presence of CTO lesions in at least one major coronary artery were retrospectively included in this study. Patients were categorized into a group with poor collateral circulation formation (Rentrop grade 0–1, n = 205) and a group with good collateral circulation formation (Rentrop grade 2–3, n = 476) according to the Rentrop scale. They were also categorized according to their glucose metabolism status: normal glucose regulation (NGR) (n = 139), prediabetes mellitus (Pre-DM) (n = 218), and diabetes mellitus (DM) (n = 324). Correlation between TyG index and collateral circulation formation was analyzed by logistic regression analysis and receiver operating characteristic (ROC) curves. Results Among patients with CTO, TyG index was significantly higher in the group with poor collateral circulation formation than in the group with good collateral circulation formation. Logistic regression analysis showed that TyG index was an independent risk factor for poor collateral circulation formation (OR 5.104, 95% CI 3.323–7.839, P < 0.001). The accuracy of TyG index in predicting collateral circulation formation was evaluated by the ROC curve, which had an area under the curve of 0.779 (95% CI 0.738–0.820, P < 0.001). The restrictive cubic spline curves showed that the risk of poor collateral circulation formation in the Pre-DM and DM groups was initially flat and finally increased rapidly, except for the NGR group. TyG index was significantly associated with an increased risk of poor collateral circulation formation in the Pre-DM and DM groups. Conclusions TyG index was significantly associated with the risk of poor collateral circulation formation in patients with CTO, especially those with Pre-DM and DM. |
| first_indexed | 2024-03-08T14:19:30Z |
| format | Article |
| id | doaj.art-bb5f2d6b872f4c58a709ec665902cab1 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-08T14:19:30Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-bb5f2d6b872f4c58a709ec665902cab12024-01-14T12:10:58ZengBMCCardiovascular Diabetology1475-28402024-01-012311910.1186/s12933-023-02080-3Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic statesJunwei Zhu0Minghui Niu1Chenxing Wang2Ying Liang3Rong Guo4Fei He5Department of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Hematology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityAbstract Background To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries in different glucose metabolic states. Methods A total of 681 patients who underwent coronary angiography between January 2020 and December 2021 to determine the presence of CTO lesions in at least one major coronary artery were retrospectively included in this study. Patients were categorized into a group with poor collateral circulation formation (Rentrop grade 0–1, n = 205) and a group with good collateral circulation formation (Rentrop grade 2–3, n = 476) according to the Rentrop scale. They were also categorized according to their glucose metabolism status: normal glucose regulation (NGR) (n = 139), prediabetes mellitus (Pre-DM) (n = 218), and diabetes mellitus (DM) (n = 324). Correlation between TyG index and collateral circulation formation was analyzed by logistic regression analysis and receiver operating characteristic (ROC) curves. Results Among patients with CTO, TyG index was significantly higher in the group with poor collateral circulation formation than in the group with good collateral circulation formation. Logistic regression analysis showed that TyG index was an independent risk factor for poor collateral circulation formation (OR 5.104, 95% CI 3.323–7.839, P < 0.001). The accuracy of TyG index in predicting collateral circulation formation was evaluated by the ROC curve, which had an area under the curve of 0.779 (95% CI 0.738–0.820, P < 0.001). The restrictive cubic spline curves showed that the risk of poor collateral circulation formation in the Pre-DM and DM groups was initially flat and finally increased rapidly, except for the NGR group. TyG index was significantly associated with an increased risk of poor collateral circulation formation in the Pre-DM and DM groups. Conclusions TyG index was significantly associated with the risk of poor collateral circulation formation in patients with CTO, especially those with Pre-DM and DM.https://doi.org/10.1186/s12933-023-02080-3Chronic total occlusionCoronary collateral circulationTriglyceride glucose indexDifferent glucose metabolic states |
| spellingShingle | Junwei Zhu Minghui Niu Chenxing Wang Ying Liang Rong Guo Fei He Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states Cardiovascular Diabetology Chronic total occlusion Coronary collateral circulation Triglyceride glucose index Different glucose metabolic states |
| title | Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| title_full | Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| title_fullStr | Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| title_full_unstemmed | Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| title_short | Correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| title_sort | correlation between triglyceride glucose index and collateral circulation formation in patients with chronic total occlusion of coronary arteries in different glucose metabolic states |
| topic | Chronic total occlusion Coronary collateral circulation Triglyceride glucose index Different glucose metabolic states |
| url | https://doi.org/10.1186/s12933-023-02080-3 |
| work_keys_str_mv | AT junweizhu correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates AT minghuiniu correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates AT chenxingwang correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates AT yingliang correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates AT rongguo correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates AT feihe correlationbetweentriglycerideglucoseindexandcollateralcirculationformationinpatientswithchronictotalocclusionofcoronaryarteriesindifferentglucosemetabolicstates |