New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/28/5/297 |
| _version_ | 1797514885839454208 |
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| author | Marie Donzel Lucile Baseggio Juliette Fontaine Florian Pesce Hervé Ghesquières Emmanuel Bachy Aurélie Verney Alexandra Traverse-Glehen |
| author_facet | Marie Donzel Lucile Baseggio Juliette Fontaine Florian Pesce Hervé Ghesquières Emmanuel Bachy Aurélie Verney Alexandra Traverse-Glehen |
| author_sort | Marie Donzel |
| collection | DOAJ |
| description | Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas. |
| first_indexed | 2024-03-10T06:38:52Z |
| format | Article |
| id | doaj.art-bb5fbb518bd4409a97444b6337e92698 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T06:38:52Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-bb5fbb518bd4409a97444b6337e926982023-11-22T17:54:33ZengMDPI AGCurrent Oncology1198-00521718-77292021-09-012853430344710.3390/curroncol28050297New Insights into the Biology and Diagnosis of Splenic Marginal Zone LymphomasMarie Donzel0Lucile Baseggio1Juliette Fontaine2Florian Pesce3Hervé Ghesquières4Emmanuel Bachy5Aurélie Verney6Alexandra Traverse-Glehen7Institut de pathologie multi-sites, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, FranceLaboratoire d’hématologie, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, FranceInstitut de pathologie multi-sites, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, FranceInstitut de pathologie multi-sites, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, FranceINSERM-Unité Mixte de Recherche 1052 CNRS 5286, Team “Clinical and Experimental Models of Lymphomagenesis”, UCBL, Cancer Research Center of Lyon, Université Lyon, 69001 Lyon, FranceINSERM-Unité Mixte de Recherche 1052 CNRS 5286, Team “Clinical and Experimental Models of Lymphomagenesis”, UCBL, Cancer Research Center of Lyon, Université Lyon, 69001 Lyon, FranceINSERM-Unité Mixte de Recherche 1052 CNRS 5286, Team “Clinical and Experimental Models of Lymphomagenesis”, UCBL, Cancer Research Center of Lyon, Université Lyon, 69001 Lyon, FranceInstitut de pathologie multi-sites, Hôpital Lyon Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, FranceSplenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas.https://www.mdpi.com/1718-7729/28/5/297splenic marginal zone lymphomareviewgeneticmolecular |
| spellingShingle | Marie Donzel Lucile Baseggio Juliette Fontaine Florian Pesce Hervé Ghesquières Emmanuel Bachy Aurélie Verney Alexandra Traverse-Glehen New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas Current Oncology splenic marginal zone lymphoma review genetic molecular |
| title | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas |
| title_full | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas |
| title_fullStr | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas |
| title_full_unstemmed | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas |
| title_short | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas |
| title_sort | new insights into the biology and diagnosis of splenic marginal zone lymphomas |
| topic | splenic marginal zone lymphoma review genetic molecular |
| url | https://www.mdpi.com/1718-7729/28/5/297 |
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