The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy
Abstract Background and aim It has been previously reported that inflow occlusion does not affect postoperative outcomes in hepatocellular carcinoma patients. However, for patients with ruptured hepatocellular carcinoma(rHCC), the effect of hepatic inflow occlusion and the number of occlusion times...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-03-01
|
| Series: | BMC Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12893-022-01537-8 |
| _version_ | 1818281352918728704 |
|---|---|
| author | Feng Xia Zhiyuan Huang Elijah Ndhlovu Mingyu Zhang Xiaoping Chen Bixiang Zhang Peng Zhu |
| author_facet | Feng Xia Zhiyuan Huang Elijah Ndhlovu Mingyu Zhang Xiaoping Chen Bixiang Zhang Peng Zhu |
| author_sort | Feng Xia |
| collection | DOAJ |
| description | Abstract Background and aim It has been previously reported that inflow occlusion does not affect postoperative outcomes in hepatocellular carcinoma patients. However, for patients with ruptured hepatocellular carcinoma(rHCC), the effect of hepatic inflow occlusion and the number of occlusion times on the prognosis is unknown. Methods 203 patients with ruptured hepatocellular carcinoma were enrolled in this study. They were first divided into the non-hepatic inflow occlusion (non-HIO) group and the hepatic inflow occlusion (HIO) group. The Kaplan–Meier method was used to compare the recurrence-free survival and overall survival between the two groups. Patients in the HIO group were further divided into one-time HIO and two times HIO groups. KM method was also used to compare the two groups. Finally, independent risk factors affecting RFS and OS were determined by multivariate Cox regression analysis. Result In the non-HIO group, 1-,3- and 5-year OS rates were 67.0%, 41.0%, and 22.0%respectively, and RFS rates were 45.0%, 31.0%, and 20.0% respectively; In the one-HIO group, the 1-,3-, and 5-year OS rates were 55.1%, 32.1%, and 19.2% respectively, and RFS rates were 33.3%, 16.7%, and 7.7% respectively; In the two-HIO group, 1-,3-, and 5-year OS rates were 24.0%, 0.0%, and 0.0% respectively, and RFS rates were 8.0%, 0.0%, and 0.0% respectively. By Cox regression analysis, HIO was an independent risk factor for a poor prognosis in rHCC patients. Conclusion One time hepatic inflow occlusion did not affect postoperative OS, but negatively affected the RFS of rHCC patients; two times hepatic inflow occlusion negatively affected the postoperative OS and RFS in patients with rHCC. |
| first_indexed | 2024-12-13T00:03:46Z |
| format | Article |
| id | doaj.art-bb61044b9e9b4c6e9d321fc7dba34462 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-13T00:03:46Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-bb61044b9e9b4c6e9d321fc7dba344622022-12-22T00:06:21ZengBMCBMC Surgery1471-24822022-03-0122111210.1186/s12893-022-01537-8The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomyFeng Xia0Zhiyuan Huang1Elijah Ndhlovu2Mingyu Zhang3Xiaoping Chen4Bixiang Zhang5Peng Zhu6Center for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyCenter for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyCenter for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyDepartment of Digestive Medicine Tongji Hospital of Tongji Medical College in Huazhong University of Science and TechnologyCenter for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyCenter for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyCenter for Hepatic Surgery, Institute of HBP Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyAbstract Background and aim It has been previously reported that inflow occlusion does not affect postoperative outcomes in hepatocellular carcinoma patients. However, for patients with ruptured hepatocellular carcinoma(rHCC), the effect of hepatic inflow occlusion and the number of occlusion times on the prognosis is unknown. Methods 203 patients with ruptured hepatocellular carcinoma were enrolled in this study. They were first divided into the non-hepatic inflow occlusion (non-HIO) group and the hepatic inflow occlusion (HIO) group. The Kaplan–Meier method was used to compare the recurrence-free survival and overall survival between the two groups. Patients in the HIO group were further divided into one-time HIO and two times HIO groups. KM method was also used to compare the two groups. Finally, independent risk factors affecting RFS and OS were determined by multivariate Cox regression analysis. Result In the non-HIO group, 1-,3- and 5-year OS rates were 67.0%, 41.0%, and 22.0%respectively, and RFS rates were 45.0%, 31.0%, and 20.0% respectively; In the one-HIO group, the 1-,3-, and 5-year OS rates were 55.1%, 32.1%, and 19.2% respectively, and RFS rates were 33.3%, 16.7%, and 7.7% respectively; In the two-HIO group, 1-,3-, and 5-year OS rates were 24.0%, 0.0%, and 0.0% respectively, and RFS rates were 8.0%, 0.0%, and 0.0% respectively. By Cox regression analysis, HIO was an independent risk factor for a poor prognosis in rHCC patients. Conclusion One time hepatic inflow occlusion did not affect postoperative OS, but negatively affected the RFS of rHCC patients; two times hepatic inflow occlusion negatively affected the postoperative OS and RFS in patients with rHCC.https://doi.org/10.1186/s12893-022-01537-8Ruptured hepatocellular carcinomaHepatic inflow occlusionHepatectomy |
| spellingShingle | Feng Xia Zhiyuan Huang Elijah Ndhlovu Mingyu Zhang Xiaoping Chen Bixiang Zhang Peng Zhu The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy BMC Surgery Ruptured hepatocellular carcinoma Hepatic inflow occlusion Hepatectomy |
| title | The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| title_full | The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| title_fullStr | The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| title_full_unstemmed | The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| title_short | The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| title_sort | effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy |
| topic | Ruptured hepatocellular carcinoma Hepatic inflow occlusion Hepatectomy |
| url | https://doi.org/10.1186/s12893-022-01537-8 |
| work_keys_str_mv | AT fengxia theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT zhiyuanhuang theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT elijahndhlovu theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT mingyuzhang theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT xiaopingchen theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT bixiangzhang theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT pengzhu theeffectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT fengxia effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT zhiyuanhuang effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT elijahndhlovu effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT mingyuzhang effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT xiaopingchen effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT bixiangzhang effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy AT pengzhu effectofthenumberofhepaticinflowocclusiontimesontheprognosisofrupturedhepatocellularcarcinomapatientsafterhepatectomy |