Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease
The World Health Organization announced that cardiovascular disease is the number one cause of death globally, representing 31% of all global deaths. Coronary artery disease (CAD) affects approximately 5% of the US population aged 40 years and older. With an age-adjusted prevalence of approximately...
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MDPI AG
2018-03-01
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| Series: | Medicines |
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| Online Access: | http://www.mdpi.com/2305-6320/5/2/31 |
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| author | Fumihiro Sanada Yoshiaki Taniyama Jun Muratsu Rei Otsu Hideo Shimizu Hiromi Rakugi Ryuichi Morishita |
| author_facet | Fumihiro Sanada Yoshiaki Taniyama Jun Muratsu Rei Otsu Hideo Shimizu Hiromi Rakugi Ryuichi Morishita |
| author_sort | Fumihiro Sanada |
| collection | DOAJ |
| description | The World Health Organization announced that cardiovascular disease is the number one cause of death globally, representing 31% of all global deaths. Coronary artery disease (CAD) affects approximately 5% of the US population aged 40 years and older. With an age-adjusted prevalence of approximately 12%, peripheral artery disease (PAD) affects at least 8 to 12 million Americans. Both CAD and PAD are caused by mainly atherosclerosis, the hardening and narrowing of arteries over the years by lipid deposition in the vascular bed. Despite the significant advances in interventions for revascularization and intensive medical care, patients with CAD or PAD who undergo percutaneous transluminal angioplasty have a persistent high rate of myocardial infarction, amputation, and death. Therefore, new therapeutic strategies are urgently needed for these patients. To overcome this unmet need, therapeutic angiogenesis using angiogenic growth factors has evolved in an attempt to stimulate the growth of new vasculature to compensate for tissue ischemia. After nearly 20 years of investigation, there is growing evidence of successful or unsuccessful gene therapy for ischemic heart and limb disease. This review will discuss basic and clinical data of therapeutic angiogenesis studies employing angiogenic growth factors for PAD patients and will draw conclusions on the basis of our current understanding of the biological processes of new vascularization. |
| first_indexed | 2024-12-21T20:11:31Z |
| format | Article |
| id | doaj.art-bb61525c2ec3497980676ea0842d4954 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-12-21T20:11:31Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-bb61525c2ec3497980676ea0842d49542022-12-21T18:51:45ZengMDPI AGMedicines2305-63202018-03-01523110.3390/medicines5020031medicines5020031Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery DiseaseFumihiro Sanada0Yoshiaki Taniyama1Jun Muratsu2Rei Otsu3Hideo Shimizu4Hiromi Rakugi5Ryuichi Morishita6Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanThe World Health Organization announced that cardiovascular disease is the number one cause of death globally, representing 31% of all global deaths. Coronary artery disease (CAD) affects approximately 5% of the US population aged 40 years and older. With an age-adjusted prevalence of approximately 12%, peripheral artery disease (PAD) affects at least 8 to 12 million Americans. Both CAD and PAD are caused by mainly atherosclerosis, the hardening and narrowing of arteries over the years by lipid deposition in the vascular bed. Despite the significant advances in interventions for revascularization and intensive medical care, patients with CAD or PAD who undergo percutaneous transluminal angioplasty have a persistent high rate of myocardial infarction, amputation, and death. Therefore, new therapeutic strategies are urgently needed for these patients. To overcome this unmet need, therapeutic angiogenesis using angiogenic growth factors has evolved in an attempt to stimulate the growth of new vasculature to compensate for tissue ischemia. After nearly 20 years of investigation, there is growing evidence of successful or unsuccessful gene therapy for ischemic heart and limb disease. This review will discuss basic and clinical data of therapeutic angiogenesis studies employing angiogenic growth factors for PAD patients and will draw conclusions on the basis of our current understanding of the biological processes of new vascularization.http://www.mdpi.com/2305-6320/5/2/31angiogenesisgene therapyhepatocyte growth factor |
| spellingShingle | Fumihiro Sanada Yoshiaki Taniyama Jun Muratsu Rei Otsu Hideo Shimizu Hiromi Rakugi Ryuichi Morishita Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease Medicines angiogenesis gene therapy hepatocyte growth factor |
| title | Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease |
| title_full | Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease |
| title_fullStr | Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease |
| title_full_unstemmed | Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease |
| title_short | Gene-Therapeutic Strategies Targeting Angiogenesis in Peripheral Artery Disease |
| title_sort | gene therapeutic strategies targeting angiogenesis in peripheral artery disease |
| topic | angiogenesis gene therapy hepatocyte growth factor |
| url | http://www.mdpi.com/2305-6320/5/2/31 |
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