Structure and spectroscopy of methionyl-methionine for aquaculture
Abstract The amino acid l-methionine is an essential amino acid and is commonly used as a feed supplement in terrestrial animals. It is less suitable for marine organisms because it is readily excreted. It is also highly water soluble and this results in loss of the feed and eutrophication of the wa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80385-z |
| _version_ | 1818716799087149056 |
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| author | Stewart F. Parker Nicholas P. Funnell Kenneth Shankland Elena A. Kabova Thomas Häußner Hans-Joachim Hasselbach Sascha Braune Christoph Kobler Peter W. Albers |
| author_facet | Stewart F. Parker Nicholas P. Funnell Kenneth Shankland Elena A. Kabova Thomas Häußner Hans-Joachim Hasselbach Sascha Braune Christoph Kobler Peter W. Albers |
| author_sort | Stewart F. Parker |
| collection | DOAJ |
| description | Abstract The amino acid l-methionine is an essential amino acid and is commonly used as a feed supplement in terrestrial animals. It is less suitable for marine organisms because it is readily excreted. It is also highly water soluble and this results in loss of the feed and eutrophication of the water. To address these problems, the dipeptide dl-methionyl-dl-methionine (trade name: AQUAVI Met-Met) has been developed as a dedicated methionine source for aquaculture. The commercial product is a mixture of a racemic crystal form of d-methionyl-d-methionine/l-methionyl-l-methionine and a racemic crystal form of d-methionyl-l-methionine/l-methionyl-d-methionine. In this work, we have computationally, structurally, spectroscopically and by electron microscopy characterised these materials. The microscopy and spectroscopy demonstrate that there is no interaction between the dd–ll and dl–ld racemates on any length scale from the macroscopic to the nanoscale. |
| first_indexed | 2024-12-17T19:25:00Z |
| format | Article |
| id | doaj.art-bb624013757d4d96bb37521e378d0756 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T19:25:00Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bb624013757d4d96bb37521e378d07562022-12-21T21:35:25ZengNature PortfolioScientific Reports2045-23222021-01-0111111410.1038/s41598-020-80385-zStructure and spectroscopy of methionyl-methionine for aquacultureStewart F. Parker0Nicholas P. Funnell1Kenneth Shankland2Elena A. Kabova3Thomas Häußner4Hans-Joachim Hasselbach5Sascha Braune6Christoph Kobler7Peter W. Albers8ISIS Facility, STFC Rutherford Appleton LaboratoryISIS Facility, STFC Rutherford Appleton LaboratorySchool of Pharmacy, University of ReadingSchool of Pharmacy, University of ReadingEvonik Nutrition and Care GmbHEvonik Nutrition and Care GmbHEvonik Nutrition and Care GmbHEvonik Nutrition and Care GmbHEvonik Operations GmbHAbstract The amino acid l-methionine is an essential amino acid and is commonly used as a feed supplement in terrestrial animals. It is less suitable for marine organisms because it is readily excreted. It is also highly water soluble and this results in loss of the feed and eutrophication of the water. To address these problems, the dipeptide dl-methionyl-dl-methionine (trade name: AQUAVI Met-Met) has been developed as a dedicated methionine source for aquaculture. The commercial product is a mixture of a racemic crystal form of d-methionyl-d-methionine/l-methionyl-l-methionine and a racemic crystal form of d-methionyl-l-methionine/l-methionyl-d-methionine. In this work, we have computationally, structurally, spectroscopically and by electron microscopy characterised these materials. The microscopy and spectroscopy demonstrate that there is no interaction between the dd–ll and dl–ld racemates on any length scale from the macroscopic to the nanoscale.https://doi.org/10.1038/s41598-020-80385-z |
| spellingShingle | Stewart F. Parker Nicholas P. Funnell Kenneth Shankland Elena A. Kabova Thomas Häußner Hans-Joachim Hasselbach Sascha Braune Christoph Kobler Peter W. Albers Structure and spectroscopy of methionyl-methionine for aquaculture Scientific Reports |
| title | Structure and spectroscopy of methionyl-methionine for aquaculture |
| title_full | Structure and spectroscopy of methionyl-methionine for aquaculture |
| title_fullStr | Structure and spectroscopy of methionyl-methionine for aquaculture |
| title_full_unstemmed | Structure and spectroscopy of methionyl-methionine for aquaculture |
| title_short | Structure and spectroscopy of methionyl-methionine for aquaculture |
| title_sort | structure and spectroscopy of methionyl methionine for aquaculture |
| url | https://doi.org/10.1038/s41598-020-80385-z |
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