Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites
Triphenyltin is an environmental contaminant widely used in antifouling paints and can cause toxicity in various organs in living organisms. However, its effects on intestinal function and the microbiome of the gut remain unknown. The objective of this study was to explore the intestinal toxicity of...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323012575 |
| _version_ | 1827609655087464448 |
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| author | Xiuxiu Chen Donghui Zhu Fan Zhang Ouyang Li Fan Yang Zhijun Bao |
| author_facet | Xiuxiu Chen Donghui Zhu Fan Zhang Ouyang Li Fan Yang Zhijun Bao |
| author_sort | Xiuxiu Chen |
| collection | DOAJ |
| description | Triphenyltin is an environmental contaminant widely used in antifouling paints and can cause toxicity in various organs in living organisms. However, its effects on intestinal function and the microbiome of the gut remain unknown. The objective of this study was to explore the intestinal toxicity of triphenyltin in mice by orally administering 0, 1.875, 3.75, and 7.5 mg/Kg to adult male mice for 8 weeks. Results showed that triphenyltin caused ileum tissue damage, induced oxidative stress, upregulated inflammation-related gene expression and increased serum tumor-necrosis factor α (TNF-α) levels in mice. Triphenyltin impaired ileum barrier function by downregulating Muc2, ZO-1, Occludin and their protein levels at 3.75 and 7.5 mg/Kg. TPT exposure led to partial inflammation and decreased mucin mRNA expression in the colon. Triphenyltin altered intestinal micro-ecological balance and fecal metabolome in mice. In conclusion, triphenyltin alters the mouse gut microbiota and fecal metabolome. |
| first_indexed | 2024-03-09T07:36:34Z |
| format | Article |
| id | doaj.art-bb63db719f334550bf1c6a9abc637f2e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-09T07:36:34Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-bb63db719f334550bf1c6a9abc637f2e2023-12-03T05:39:26ZengElsevierEcotoxicology and Environmental Safety0147-65132024-01-01269115753Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolitesXiuxiu Chen0Donghui Zhu1Fan Zhang2Ouyang Li3Fan Yang4Zhijun Bao5Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, ChinaThe Department of Cardiovascular and Thoracic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaDepartment of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, ChinaDepartment of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, ChinaDepartment of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China; Corresponding authors at: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China, Fudan University, Shanghai, China; Corresponding authors at: Department of Gerontology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.Triphenyltin is an environmental contaminant widely used in antifouling paints and can cause toxicity in various organs in living organisms. However, its effects on intestinal function and the microbiome of the gut remain unknown. The objective of this study was to explore the intestinal toxicity of triphenyltin in mice by orally administering 0, 1.875, 3.75, and 7.5 mg/Kg to adult male mice for 8 weeks. Results showed that triphenyltin caused ileum tissue damage, induced oxidative stress, upregulated inflammation-related gene expression and increased serum tumor-necrosis factor α (TNF-α) levels in mice. Triphenyltin impaired ileum barrier function by downregulating Muc2, ZO-1, Occludin and their protein levels at 3.75 and 7.5 mg/Kg. TPT exposure led to partial inflammation and decreased mucin mRNA expression in the colon. Triphenyltin altered intestinal micro-ecological balance and fecal metabolome in mice. In conclusion, triphenyltin alters the mouse gut microbiota and fecal metabolome.http://www.sciencedirect.com/science/article/pii/S0147651323012575TriphenyltinGut microbiotaMetabolitesIntestinal barrier function |
| spellingShingle | Xiuxiu Chen Donghui Zhu Fan Zhang Ouyang Li Fan Yang Zhijun Bao Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites Ecotoxicology and Environmental Safety Triphenyltin Gut microbiota Metabolites Intestinal barrier function |
| title | Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites |
| title_full | Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites |
| title_fullStr | Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites |
| title_full_unstemmed | Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites |
| title_short | Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites |
| title_sort | exposure to triphenyltin impairs gut integrity disturbs gut microbiota and alters fecal metabolites |
| topic | Triphenyltin Gut microbiota Metabolites Intestinal barrier function |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323012575 |
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