Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study
Accumulating evidence from neuroimaging studies has supported that chronic pain could induce changes in brain function. However, few studies have focused on the dynamic regional homogeneity (dReHo) of trigeminal neuralgia (TN). In this study, twenty-eight TN patients and 28 healthy controls (HC) wer...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-10-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01083/full |
| _version_ | 1819169341380231168 |
|---|---|
| author | Jianhao Yan Jianhao Yan Meng Li Shishun Fu Guomin Li Tianyue Wang Yi Yin Guihua Jiang Jingzhi Lin Wuming Li Jin Fang Junzhang Tian Junzhang Tian |
| author_facet | Jianhao Yan Jianhao Yan Meng Li Shishun Fu Guomin Li Tianyue Wang Yi Yin Guihua Jiang Jingzhi Lin Wuming Li Jin Fang Junzhang Tian Junzhang Tian |
| author_sort | Jianhao Yan |
| collection | DOAJ |
| description | Accumulating evidence from neuroimaging studies has supported that chronic pain could induce changes in brain function. However, few studies have focused on the dynamic regional homogeneity (dReHo) of trigeminal neuralgia (TN). In this study, twenty-eight TN patients and 28 healthy controls (HC) were included. Based on the resting-state fMRI (rsfMRI), we detected abnormalities in dReHo in the TN patients. Patients with TN had decreased dReHo in the left middle temporal gyrus, superior parietal lobule, and precentral gyrus, and increased dReHo in the thalamus. Furthermore, the increase in dReHo in the thalamus was positively correlated with duration of TN (r = 0.485, p = 0.012). These results provide compelling evidence for abnormal resting-state brain activity in TN and suggest that the duration of TN may play a critical role in brain function. |
| first_indexed | 2024-12-22T19:17:58Z |
| format | Article |
| id | doaj.art-bb66de220cac451fa767b38e3b80c733 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T19:17:58Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-bb66de220cac451fa767b38e3b80c7332022-12-21T18:15:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-10-011010.3389/fneur.2019.01083486267Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI StudyJianhao Yan0Jianhao Yan1Meng Li2Shishun Fu3Guomin Li4Tianyue Wang5Yi Yin6Guihua Jiang7Jingzhi Lin8Wuming Li9Jin Fang10Junzhang Tian11Junzhang Tian12The Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Neruosurgery, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaThe Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, ChinaAccumulating evidence from neuroimaging studies has supported that chronic pain could induce changes in brain function. However, few studies have focused on the dynamic regional homogeneity (dReHo) of trigeminal neuralgia (TN). In this study, twenty-eight TN patients and 28 healthy controls (HC) were included. Based on the resting-state fMRI (rsfMRI), we detected abnormalities in dReHo in the TN patients. Patients with TN had decreased dReHo in the left middle temporal gyrus, superior parietal lobule, and precentral gyrus, and increased dReHo in the thalamus. Furthermore, the increase in dReHo in the thalamus was positively correlated with duration of TN (r = 0.485, p = 0.012). These results provide compelling evidence for abnormal resting-state brain activity in TN and suggest that the duration of TN may play a critical role in brain function.https://www.frontiersin.org/article/10.3389/fneur.2019.01083/fulltrigeminal neuralgiaresting-state fMRIdynamic regional homogeneitypain durationbrain function |
| spellingShingle | Jianhao Yan Jianhao Yan Meng Li Shishun Fu Guomin Li Tianyue Wang Yi Yin Guihua Jiang Jingzhi Lin Wuming Li Jin Fang Junzhang Tian Junzhang Tian Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study Frontiers in Neurology trigeminal neuralgia resting-state fMRI dynamic regional homogeneity pain duration brain function |
| title | Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study |
| title_full | Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study |
| title_fullStr | Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study |
| title_full_unstemmed | Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study |
| title_short | Alterations of Dynamic Regional Homogeneity in Trigeminal Neuralgia: A Resting-State fMRI Study |
| title_sort | alterations of dynamic regional homogeneity in trigeminal neuralgia a resting state fmri study |
| topic | trigeminal neuralgia resting-state fMRI dynamic regional homogeneity pain duration brain function |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01083/full |
| work_keys_str_mv | AT jianhaoyan alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT jianhaoyan alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT mengli alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT shishunfu alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT guominli alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT tianyuewang alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT yiyin alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT guihuajiang alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT jingzhilin alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT wumingli alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT jinfang alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT junzhangtian alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy AT junzhangtian alterationsofdynamicregionalhomogeneityintrigeminalneuralgiaarestingstatefmristudy |