Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study
<p>Abstract</p> <p>Backround</p> <p>To evaluate the importance of oral glucose tolerance test (OGTT) in predicting diabetes and cardiovascular disease in patients with and without Metabolic Syndrome from a population treated in a primary care unit.</p> <p>Re...
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://www.dmsjournal.com/content/4/1/25 |
| _version_ | 1818474238607097856 |
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| author | Furtado de Souza Camila Dalzochio Mériane de Oliveira Francisco Jorge Gross Jorge Leitão Cristiane |
| author_facet | Furtado de Souza Camila Dalzochio Mériane de Oliveira Francisco Jorge Gross Jorge Leitão Cristiane |
| author_sort | Furtado de Souza Camila |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Backround</p> <p>To evaluate the importance of oral glucose tolerance test (OGTT) in predicting diabetes and cardiovascular disease in patients with and without Metabolic Syndrome from a population treated in a primary care unit.</p> <p>Research design and methods</p> <p>A prospective cohort study was conducted with subjects regularly attending the primary care unit of Hospital de Clínicas de Porto Alegre. Participants underwent a 75 g OGTT. Metabolic syndrome definition was based on the criteria of IDF/AHA/NHLBI-2010.</p> <p>Results</p> <p>Participants mean age was 61 ± 12 years (males: 38%; whites: 67%). Of the 148 subjects included, 127 (86%) were followed for 36 ± 14 months, 21 (14%) were lost. Subjects were classified into four groups based on baseline OGTT: 29% normal (n = 43), 28% impaired fasting glucose (IFG; n = 42), 26% impaired glucose tolerance (IGT; n = 38), and 17% diabetes (n = 25). Metabolic syndrome prevalence was lower in normal group (28%), intermediate in IFG (62%) and IGT (65%) groups, and higher among subjects with diabetes (92%; P <0.001). Incidence of diabetes increased along with the stages of glucose metabolism disturbance (normal: 0%, IFG: 16%, IGT: 28%; P = 0.004). No patient with normal OGTT developed diabetes, regardless metabolic syndrome presence. Diabetes at baseline was the major determinant of cardiovascular disease occurrence (normal: 0%, IFG: 4%, IGT: 0%, diabetes: 24%; P = 0.001). In Cox-regression analysis, only the 2 h OGTT results were associated with diabetes (OR = 1.03; 95%CI 1.01–1.06; P <0.001) and cardiovascular disease development (OR = 1.013; 95%CI 1.002–1.025; P = 0.024).</p> <p>Conclusions</p> <p>In this sample of subjects undergoing diabetes screening, the OGTT predicted diabetes and cardiovascular disease more effectively than the metabolic syndrome status.</p> |
| first_indexed | 2024-04-14T04:34:17Z |
| format | Article |
| id | doaj.art-bb6878694dc249dda18ad1a63a4c390b |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-14T04:34:17Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-bb6878694dc249dda18ad1a63a4c390b2022-12-22T02:11:57ZengBMCDiabetology & Metabolic Syndrome1758-59962012-06-01412510.1186/1758-5996-4-25Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort studyFurtado de Souza CamilaDalzochio Mérianede Oliveira Francisco JorgeGross JorgeLeitão Cristiane<p>Abstract</p> <p>Backround</p> <p>To evaluate the importance of oral glucose tolerance test (OGTT) in predicting diabetes and cardiovascular disease in patients with and without Metabolic Syndrome from a population treated in a primary care unit.</p> <p>Research design and methods</p> <p>A prospective cohort study was conducted with subjects regularly attending the primary care unit of Hospital de Clínicas de Porto Alegre. Participants underwent a 75 g OGTT. Metabolic syndrome definition was based on the criteria of IDF/AHA/NHLBI-2010.</p> <p>Results</p> <p>Participants mean age was 61 ± 12 years (males: 38%; whites: 67%). Of the 148 subjects included, 127 (86%) were followed for 36 ± 14 months, 21 (14%) were lost. Subjects were classified into four groups based on baseline OGTT: 29% normal (n = 43), 28% impaired fasting glucose (IFG; n = 42), 26% impaired glucose tolerance (IGT; n = 38), and 17% diabetes (n = 25). Metabolic syndrome prevalence was lower in normal group (28%), intermediate in IFG (62%) and IGT (65%) groups, and higher among subjects with diabetes (92%; P <0.001). Incidence of diabetes increased along with the stages of glucose metabolism disturbance (normal: 0%, IFG: 16%, IGT: 28%; P = 0.004). No patient with normal OGTT developed diabetes, regardless metabolic syndrome presence. Diabetes at baseline was the major determinant of cardiovascular disease occurrence (normal: 0%, IFG: 4%, IGT: 0%, diabetes: 24%; P = 0.001). In Cox-regression analysis, only the 2 h OGTT results were associated with diabetes (OR = 1.03; 95%CI 1.01–1.06; P <0.001) and cardiovascular disease development (OR = 1.013; 95%CI 1.002–1.025; P = 0.024).</p> <p>Conclusions</p> <p>In this sample of subjects undergoing diabetes screening, the OGTT predicted diabetes and cardiovascular disease more effectively than the metabolic syndrome status.</p>http://www.dmsjournal.com/content/4/1/25impaired fasting glucoseimpaired glucose tolerancetype 2 diabetesmetabolic syndromecardiovascular disease |
| spellingShingle | Furtado de Souza Camila Dalzochio Mériane de Oliveira Francisco Jorge Gross Jorge Leitão Cristiane Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study Diabetology & Metabolic Syndrome impaired fasting glucose impaired glucose tolerance type 2 diabetes metabolic syndrome cardiovascular disease |
| title | Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study |
| title_full | Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study |
| title_fullStr | Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study |
| title_full_unstemmed | Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study |
| title_short | Glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome: a prospective cohort study |
| title_sort | glucose tolerance status is a better predictor of diabetes and cardiovascular outcomes than metabolic syndrome a prospective cohort study |
| topic | impaired fasting glucose impaired glucose tolerance type 2 diabetes metabolic syndrome cardiovascular disease |
| url | http://www.dmsjournal.com/content/4/1/25 |
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