Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency
Introduction: The presence of symptoms, systolic dysfunction and Left Ventricle (LV) dilation are considered unfavourable prognostic markers in Aortic Valve Insufficiency (AVI). The role of diastolic dysfunction, which is considered unfavourable outcome marker in cardiac pathologies, is not well...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9974/23463_CE[Ra1]_F(GH)_PF1(SG_SS)_PFA(NC)_PF2(P_VD_NE).pdf |
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| author | Meliza Goi Roscani Juliana Da Cunha Duarte Gustavo Nicolodi Augusto Thaysa Rodrigues De Moraes Salgueiro Mariana N Meireles Juliana I.F. Gobbi Katashi Okoshi João Carlos Hueb |
| author_facet | Meliza Goi Roscani Juliana Da Cunha Duarte Gustavo Nicolodi Augusto Thaysa Rodrigues De Moraes Salgueiro Mariana N Meireles Juliana I.F. Gobbi Katashi Okoshi João Carlos Hueb |
| author_sort | Meliza Goi Roscani |
| collection | DOAJ |
| description | Introduction: The presence of symptoms, systolic dysfunction
and Left Ventricle (LV) dilation are considered unfavourable
prognostic markers in Aortic Valve Insufficiency (AVI). The role
of diastolic dysfunction, which is considered unfavourable
outcome marker in cardiac pathologies, is not well established
in AVI.
Aim: To evaluate if the presence of diastolic dysfunction may
be associated with unfavourable prognostic markers in AVI
patients.
Materials and Methods: A cross-sectional prospective study was performed on 22 patients with moderate or severe AVI. They underwent
clinical evaluation and transthoracic echocardiography. Associations between clinical, epidemiological and echocardiographic
were evaluated by Student t-test for normally distributed variables or Mann-Whitney test for non-normal distribution. Comparison between proportions was performed by Chi-square
test.
Results: There was an association between increased LV filling
pressure, assessed by E’ and E/E’ of Mitral Tissue Doppler,
and impaired LV systolic function, respectively: R = 0.563, R2
=
0.281; p = 0.008 and R = 0.639, R2
= 0.378; p = 0.002. The LV
indexed mass also was inversely associated with the LV ejection
fraction (R = 0.62, R2
= 0.35 and p = 0.003).
Conclusion: There was an association of LV diastolic dysfunction
and ventricular hypertrophy with impaired left ventricle systolic
function. Increased LV filling pressure and LV indexed mass
should be considered in the management of AVI patients. |
| first_indexed | 2024-12-11T01:17:02Z |
| format | Article |
| id | doaj.art-bb68c724094340488d7d42c17f821548 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T01:17:02Z |
| publishDate | 2017-06-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-bb68c724094340488d7d42c17f8215482022-12-22T01:25:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-06-01116OC09OC1110.7860/JCDR/2017/23463.9974Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic InsufficiencyMeliza Goi Roscani0Juliana Da Cunha Duarte1Gustavo Nicolodi Augusto2Thaysa Rodrigues De Moraes Salgueiro3Mariana N Meireles4Juliana I.F. Gobbi5Katashi Okoshi6João Carlos Hueb7Consultant, Department of Medical Medicine, São Carlos Federal University, São Carlos, São Paulo, Brazil.Consultant, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Consultant, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Consultant, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Consultant, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Professor, Department of Biosciences Institute, São Paulo State University, Botucatu, São Paulo, Brazil.Consultant, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Professor, Department of Internal Medicine, Botucatu Medical School, Botucatu, São Paulo, Brazil.Introduction: The presence of symptoms, systolic dysfunction and Left Ventricle (LV) dilation are considered unfavourable prognostic markers in Aortic Valve Insufficiency (AVI). The role of diastolic dysfunction, which is considered unfavourable outcome marker in cardiac pathologies, is not well established in AVI. Aim: To evaluate if the presence of diastolic dysfunction may be associated with unfavourable prognostic markers in AVI patients. Materials and Methods: A cross-sectional prospective study was performed on 22 patients with moderate or severe AVI. They underwent clinical evaluation and transthoracic echocardiography. Associations between clinical, epidemiological and echocardiographic were evaluated by Student t-test for normally distributed variables or Mann-Whitney test for non-normal distribution. Comparison between proportions was performed by Chi-square test. Results: There was an association between increased LV filling pressure, assessed by E’ and E/E’ of Mitral Tissue Doppler, and impaired LV systolic function, respectively: R = 0.563, R2 = 0.281; p = 0.008 and R = 0.639, R2 = 0.378; p = 0.002. The LV indexed mass also was inversely associated with the LV ejection fraction (R = 0.62, R2 = 0.35 and p = 0.003). Conclusion: There was an association of LV diastolic dysfunction and ventricular hypertrophy with impaired left ventricle systolic function. Increased LV filling pressure and LV indexed mass should be considered in the management of AVI patients.https://jcdr.net/articles/PDF/9974/23463_CE[Ra1]_F(GH)_PF1(SG_SS)_PFA(NC)_PF2(P_VD_NE).pdfechocardiogramleft ventricle filling pressuremyocardial eccentric hypertrophyvolume overload |
| spellingShingle | Meliza Goi Roscani Juliana Da Cunha Duarte Gustavo Nicolodi Augusto Thaysa Rodrigues De Moraes Salgueiro Mariana N Meireles Juliana I.F. Gobbi Katashi Okoshi João Carlos Hueb Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency Journal of Clinical and Diagnostic Research echocardiogram left ventricle filling pressure myocardial eccentric hypertrophy volume overload |
| title | Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency |
| title_full | Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency |
| title_fullStr | Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency |
| title_full_unstemmed | Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency |
| title_short | Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency |
| title_sort | association between left ventricle diastolic dysfunction and unfavorable prognostic markers in patients with aortic insufficiency |
| topic | echocardiogram left ventricle filling pressure myocardial eccentric hypertrophy volume overload |
| url | https://jcdr.net/articles/PDF/9974/23463_CE[Ra1]_F(GH)_PF1(SG_SS)_PFA(NC)_PF2(P_VD_NE).pdf |
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