Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis

Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis

Rheumatoid arthritis (RA) is a complex autoimmune condition primarily affecting synovial joints, which targeted synthetic drugs have damaging safety issues. Saussurea laniceps, a reputed anti-rheumatic medicinal herb, is an excellent place to start looking for natural products as safe, effective, ta...

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Bibliographic Details
Main Authors: Qilei Chen, Wenmin Zhou, Yueming Huang, Yuanyang Tian, Sum Yi Wong, Wing Ki Lam, Ka Yee Ying, Jianye Zhang, Hubiao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
Saussurea laniceps
ultrafiltration
network pharmacology
ErbB network
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.946210/full

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