Treatment of Major Depressive Disorder in Pediatric Populations
Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence. Unfortunately, many pediatric patients suffering from MDD go undiagnosed, and current evidence-based treatm...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Diseases |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-9721/6/2/48 |
| _version_ | 1818489356124422144 |
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| author | Drew R. Neavin Jeremiah Joyce Cosima Swintak |
| author_facet | Drew R. Neavin Jeremiah Joyce Cosima Swintak |
| author_sort | Drew R. Neavin |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence. Unfortunately, many pediatric patients suffering from MDD go undiagnosed, and current evidence-based treatment options in the U.S. are limited to psychotherapy and two selective serotonin reuptake inhibitors approved by the United States Food and Drug Administration. Molecular mechanisms have been shown to play a role in MDD pathogenesis, progression, and response to medication, yet few studies have explored the role of these pathways in pediatric MDD. In this review, we outline the gravity and importance of MDD in pediatric patients, some challenges in diagnosis and treatment, current treatments available for pediatric patients, and research to investigate differences between pediatric and adult MDD. We hope that this review will provide an outline of the current understanding and treatment of MDD in pediatric patients, and provide thoughtful insights for future work that could advance our understanding of MDD in pediatric populations, and also identify new therapeutic strategies. |
| first_indexed | 2024-12-10T17:02:47Z |
| format | Article |
| id | doaj.art-bb6e39a73eaf45db902baaab0a338586 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-12-10T17:02:47Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-bb6e39a73eaf45db902baaab0a3385862022-12-22T01:40:32ZengMDPI AGDiseases2079-97212018-06-01624810.3390/diseases6020048diseases6020048Treatment of Major Depressive Disorder in Pediatric PopulationsDrew R. Neavin0Jeremiah Joyce1Cosima Swintak2Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55902, USAMayo Clinic School of Medicine, Mayo Clinic, Rochester, MN 55902, USADepartment of Psychiatry, College of Medicine, Rochester, MN 55902, USAMajor depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence. Unfortunately, many pediatric patients suffering from MDD go undiagnosed, and current evidence-based treatment options in the U.S. are limited to psychotherapy and two selective serotonin reuptake inhibitors approved by the United States Food and Drug Administration. Molecular mechanisms have been shown to play a role in MDD pathogenesis, progression, and response to medication, yet few studies have explored the role of these pathways in pediatric MDD. In this review, we outline the gravity and importance of MDD in pediatric patients, some challenges in diagnosis and treatment, current treatments available for pediatric patients, and research to investigate differences between pediatric and adult MDD. We hope that this review will provide an outline of the current understanding and treatment of MDD in pediatric patients, and provide thoughtful insights for future work that could advance our understanding of MDD in pediatric populations, and also identify new therapeutic strategies.http://www.mdpi.com/2079-9721/6/2/48major depressive disorderpediatricstreatment |
| spellingShingle | Drew R. Neavin Jeremiah Joyce Cosima Swintak Treatment of Major Depressive Disorder in Pediatric Populations Diseases major depressive disorder pediatrics treatment |
| title | Treatment of Major Depressive Disorder in Pediatric Populations |
| title_full | Treatment of Major Depressive Disorder in Pediatric Populations |
| title_fullStr | Treatment of Major Depressive Disorder in Pediatric Populations |
| title_full_unstemmed | Treatment of Major Depressive Disorder in Pediatric Populations |
| title_short | Treatment of Major Depressive Disorder in Pediatric Populations |
| title_sort | treatment of major depressive disorder in pediatric populations |
| topic | major depressive disorder pediatrics treatment |
| url | http://www.mdpi.com/2079-9721/6/2/48 |
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