Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Abstract Background Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal squamous cell carcinoma (ESCC) remains elusive. This study was conducted...

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Bibliographic Details
Main Authors: Zhi-Qiang Ma, Ying-Tong Feng, Kai Guo, Dong Liu, Chang-Jian Shao, Ming-Hong Pan, Yi-Meng Zhang, Yu-Xi Zhang, Di Lu, Di Huang, Fan Zhang, Jin-Liang Wang, Bo Yang, Jing Han, Xiao-Long Yan, Yi Hu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Military Medical Research
Subjects:
Melatonin
Histone deacetylase 7 (HDAC7)
β-catenin
c-Myc
Ubiquitin-specific peptidase 10 (USP10)
Esophageal squamous cell carcinoma (ESCC)
Online Access:https://doi.org/10.1186/s40779-022-00412-0

Internet

https://doi.org/10.1186/s40779-022-00412-0

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