Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia
The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Codon Publications
2019-09-01
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| Series: | Journal of Renal and Hepatic Disorders |
| Subjects: | |
| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/56 |
| _version_ | 1818058383114108928 |
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| author | Jan Freeman Andrew Austin Ernesto Robalino Gonzaga |
| author_facet | Jan Freeman Andrew Austin Ernesto Robalino Gonzaga |
| author_sort | Jan Freeman |
| collection | DOAJ |
| description | The complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especially in patients who are awaiting liver transplantation. An understanding of the pathophysiology of muscle protein homeostasis has led to several proposed mechanisms of sarcopenia and the potential to reverse muscle loss. This review discusses the potential mechanisms of sarcopenia and highlights the possible future means of reversing sarcopenia. |
| first_indexed | 2024-12-10T12:59:45Z |
| format | Article |
| id | doaj.art-bb7044e4471044f68cc853dc4d77e3fd |
| institution | Directory Open Access Journal |
| issn | 2207-3744 |
| language | English |
| last_indexed | 2024-12-10T12:59:45Z |
| publishDate | 2019-09-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj.art-bb7044e4471044f68cc853dc4d77e3fd2022-12-22T01:47:59ZengCodon PublicationsJournal of Renal and Hepatic Disorders2207-37442019-09-013110.15586/jrenhep.2019.56Wasting Away with Cirrhosis: A Review of Hepatic SarcopeniaJan Freeman0Andrew Austin1Ernesto Robalino Gonzaga2Hepatology Unit, University Hospitals of Derby and Burton on Trent, Derby, UKHepatology Unit, University Hospitals of Derby and Burton on Trent, Derby, UKDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, USAThe complications of decompensated cirrhosis are well documented and include variceal bleeding, fluid retention, and hepatic encephalopathy. A less well recognized complication of cirrhosis is muscle wasting or sarcopenia. It is now recognized to have a significant impact on patient survival, especially in patients who are awaiting liver transplantation. An understanding of the pathophysiology of muscle protein homeostasis has led to several proposed mechanisms of sarcopenia and the potential to reverse muscle loss. This review discusses the potential mechanisms of sarcopenia and highlights the possible future means of reversing sarcopenia.https://jrenhep.com/index.php/jrenhep/article/view/56sarcopeniacirrhosiswastingend-stage liver diseasemuscle |
| spellingShingle | Jan Freeman Andrew Austin Ernesto Robalino Gonzaga Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia Journal of Renal and Hepatic Disorders sarcopenia cirrhosis wasting end-stage liver disease muscle |
| title | Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia |
| title_full | Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia |
| title_fullStr | Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia |
| title_full_unstemmed | Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia |
| title_short | Wasting Away with Cirrhosis: A Review of Hepatic Sarcopenia |
| title_sort | wasting away with cirrhosis a review of hepatic sarcopenia |
| topic | sarcopenia cirrhosis wasting end-stage liver disease muscle |
| url | https://jrenhep.com/index.php/jrenhep/article/view/56 |
| work_keys_str_mv | AT janfreeman wastingawaywithcirrhosisareviewofhepaticsarcopenia AT andrewaustin wastingawaywithcirrhosisareviewofhepaticsarcopenia AT ernestorobalinogonzaga wastingawaywithcirrhosisareviewofhepaticsarcopenia |