Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology
Abstract Background Corneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis of corneal surgery. Clinical available devices such as Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (Corvis ST) can provide...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12938-019-0662-1 |
| _version_ | 1818962126920744960 |
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| author | Xiao Qin Lei Tian Haixia Zhang Xinyan Chen Lin Li |
| author_facet | Xiao Qin Lei Tian Haixia Zhang Xinyan Chen Lin Li |
| author_sort | Xiao Qin |
| collection | DOAJ |
| description | Abstract Background Corneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis of corneal surgery. Clinical available devices such as Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (Corvis ST) can provide corneal biomechanics related parameters, while corneal elastic modulus cannot be extracted directly from them at present. The aim of this study is to suggest a method to determine corneal elastic modulus based on the results of Corvis ST test according to Reissner’s theory on the relation between stress and small displacement in shallow spherical shell. Results Five rabbits (10 eyes) and 10 healthy humans (20 eyes) were measured with Corvis ST to obtain the normal range of corneal elastic modulus. Results showed Corneal elastic modulus of rabbit was 0.16 MPa to 0.35 MPa, human corneal elastic modulus was 0.16–0.30 MPa. Rabbit corneas were also measured at different intraocular pressures (IOP), and results showed corneal elastic modulus, first applanation time (A1T) and stiffness parameter (SP-A1) were positively correlated with IOP. Deformation amplitude (DA), the second applanations time (A2T), and peak distance (PD) were negatively correlated with IOP. Finite element method was used to simulate the Corvis measurements according to the calculated elastic modulus and the simulated corneal apical displacements were agreement with experimental results in general. Conclusions The method to determine corneal elastic modulus based on Corvis test according to the relationship between force and displacements of shallow spherical shell is convenient and effective. |
| first_indexed | 2024-12-20T12:24:22Z |
| format | Article |
| id | doaj.art-bb70fa22400b423b8683b66ec64b5372 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-20T12:24:22Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-bb70fa22400b423b8683b66ec64b53722022-12-21T19:40:54ZengBMCBioMedical Engineering OnLine1475-925X2019-04-0118111610.1186/s12938-019-0662-1Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug TechnologyXiao Qin0Lei Tian1Haixia Zhang2Xinyan Chen3Lin Li4Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical UniversityBeijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical UniversityBeijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical UniversityAbstract Background Corneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis of corneal surgery. Clinical available devices such as Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (Corvis ST) can provide corneal biomechanics related parameters, while corneal elastic modulus cannot be extracted directly from them at present. The aim of this study is to suggest a method to determine corneal elastic modulus based on the results of Corvis ST test according to Reissner’s theory on the relation between stress and small displacement in shallow spherical shell. Results Five rabbits (10 eyes) and 10 healthy humans (20 eyes) were measured with Corvis ST to obtain the normal range of corneal elastic modulus. Results showed Corneal elastic modulus of rabbit was 0.16 MPa to 0.35 MPa, human corneal elastic modulus was 0.16–0.30 MPa. Rabbit corneas were also measured at different intraocular pressures (IOP), and results showed corneal elastic modulus, first applanation time (A1T) and stiffness parameter (SP-A1) were positively correlated with IOP. Deformation amplitude (DA), the second applanations time (A2T), and peak distance (PD) were negatively correlated with IOP. Finite element method was used to simulate the Corvis measurements according to the calculated elastic modulus and the simulated corneal apical displacements were agreement with experimental results in general. Conclusions The method to determine corneal elastic modulus based on Corvis test according to the relationship between force and displacements of shallow spherical shell is convenient and effective.http://link.springer.com/article/10.1186/s12938-019-0662-1Corneal Visualization Scheimpflug Technology (Corvis ST)Reisner’s theoryCorneaElastic modulusIntraocular pressure (IOP) |
| spellingShingle | Xiao Qin Lei Tian Haixia Zhang Xinyan Chen Lin Li Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology BioMedical Engineering OnLine Corneal Visualization Scheimpflug Technology (Corvis ST) Reisner’s theory Cornea Elastic modulus Intraocular pressure (IOP) |
| title | Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology |
| title_full | Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology |
| title_fullStr | Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology |
| title_full_unstemmed | Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology |
| title_short | Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology |
| title_sort | evaluation of corneal elastic modulus based on corneal visualization scheimpflug technology |
| topic | Corneal Visualization Scheimpflug Technology (Corvis ST) Reisner’s theory Cornea Elastic modulus Intraocular pressure (IOP) |
| url | http://link.springer.com/article/10.1186/s12938-019-0662-1 |
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