WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors
Obesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance. Exercise and weight loss are associated with decreased breast cancer recurrence, which may be mediated through reduced insulin levels and improved insulin sensitivity. This is a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/3108 |
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| author | Nicholas J. D’Alonzo Lin Qiu Dorothy D. Sears Vernon Chinchilli Justin C. Brown David B. Sarwer Kathryn H. Schmitz Kathleen M. Sturgeon |
| author_facet | Nicholas J. D’Alonzo Lin Qiu Dorothy D. Sears Vernon Chinchilli Justin C. Brown David B. Sarwer Kathryn H. Schmitz Kathleen M. Sturgeon |
| author_sort | Nicholas J. D’Alonzo |
| collection | DOAJ |
| description | Obesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance. Exercise and weight loss are associated with decreased breast cancer recurrence, which may be mediated through reduced insulin levels and improved insulin sensitivity. This is a secondary analysis of the WISER Survivor clinical trial examining the relative effect of exercise, weight loss and combined exercise and weight loss interventions on insulin and insulin resistance. The weight loss and combined intervention groups showed significant reductions in levels of: insulin, C-peptide, homeostatic model assessment 2 (HOMA2) insulin resistance (IR), and HOMA2 beta-cell function (β) compared to the control group. Independent of intervention group, weight loss of ≥10% was associated with decreased levels of insulin, C-peptide, and HOMA2-IR compared to 0–5% weight loss. Further, the combination of exercise and weight loss was particularly important for breast cancer survivors with clinically abnormal levels of C-peptide. |
| first_indexed | 2024-03-10T07:20:35Z |
| format | Article |
| id | doaj.art-bb714ce58e684a20a06f327b7da4fc20 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:20:35Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bb714ce58e684a20a06f327b7da4fc202023-11-22T14:37:29ZengMDPI AGNutrients2072-66432021-09-01139310810.3390/nu13093108WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer SurvivorsNicholas J. D’Alonzo0Lin Qiu1Dorothy D. Sears2Vernon Chinchilli3Justin C. Brown4David B. Sarwer5Kathryn H. Schmitz6Kathleen M. Sturgeon7College of Medicine, Pennsylvania State University, Hershey, PA 17033, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USACancer Metabolism Program, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USACenter for Obesity Research and Education, Temple University, Philadelphia, PA 19122, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USADepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USAObesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance. Exercise and weight loss are associated with decreased breast cancer recurrence, which may be mediated through reduced insulin levels and improved insulin sensitivity. This is a secondary analysis of the WISER Survivor clinical trial examining the relative effect of exercise, weight loss and combined exercise and weight loss interventions on insulin and insulin resistance. The weight loss and combined intervention groups showed significant reductions in levels of: insulin, C-peptide, homeostatic model assessment 2 (HOMA2) insulin resistance (IR), and HOMA2 beta-cell function (β) compared to the control group. Independent of intervention group, weight loss of ≥10% was associated with decreased levels of insulin, C-peptide, and HOMA2-IR compared to 0–5% weight loss. Further, the combination of exercise and weight loss was particularly important for breast cancer survivors with clinically abnormal levels of C-peptide.https://www.mdpi.com/2072-6643/13/9/3108breast neoplasmsneoplasm recurrenceweight reduction programresistance trainingoverweightadiposity |
| spellingShingle | Nicholas J. D’Alonzo Lin Qiu Dorothy D. Sears Vernon Chinchilli Justin C. Brown David B. Sarwer Kathryn H. Schmitz Kathleen M. Sturgeon WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors Nutrients breast neoplasms neoplasm recurrence weight reduction program resistance training overweight adiposity |
| title | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors |
| title_full | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors |
| title_fullStr | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors |
| title_full_unstemmed | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors |
| title_short | WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors |
| title_sort | wiser survivor trial combined effect of exercise and weight loss interventions on insulin and insulin resistance in breast cancer survivors |
| topic | breast neoplasms neoplasm recurrence weight reduction program resistance training overweight adiposity |
| url | https://www.mdpi.com/2072-6643/13/9/3108 |
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