Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity
Thermal ablation is a minimally or noninvasive cancer therapy technique that involves fewer complications, shorter hospital stays, and fewer costs. In this paper, a thermal-ablation bioheat model for cancer treatment is numerically investigated, using a porous media-based model. The main objective i...
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MDPI AG
2021-04-01
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| Series: | Computation |
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| Online Access: | https://www.mdpi.com/2079-3197/9/5/50 |
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| author | Assunta Andreozzi Luca Brunese Marcello Iasiello Claudio Tucci Giuseppe Peter Vanoli |
| author_facet | Assunta Andreozzi Luca Brunese Marcello Iasiello Claudio Tucci Giuseppe Peter Vanoli |
| author_sort | Assunta Andreozzi |
| collection | DOAJ |
| description | Thermal ablation is a minimally or noninvasive cancer therapy technique that involves fewer complications, shorter hospital stays, and fewer costs. In this paper, a thermal-ablation bioheat model for cancer treatment is numerically investigated, using a porous media-based model. The main objective is to evaluate the effects of a variable blood volume fraction in the tumoral tissue (i.e., the porosity), in order to develop a more realistic model. A modified local thermal nonequilibrium model (LTNE) is implemented including the water content vaporization in the two phases separately and introducing the variable porosity in the domain, described by a quadratic function changing from the core to the rim of the tumoral sphere. The equations are numerically solved employing the finite-element commercial code COMSOL Multiphysics. Results are compared with the results obtained employing two uniform porosity values (ε = 0.07 and ε = 0.23) in terms of coagulation zones at the end of the heating period, maximum temperatures reached in the domain, and temperature fields and they are presented for different blood vessels. The outcomes highlight how important is to predict coagulation zones achieved in thermal ablation accurately. In this way, indeed, incomplete ablation, tumor recurrence, or healthy tissue necrosis can be avoided, and medical protocols and devices can be improved. |
| first_indexed | 2024-03-10T12:03:08Z |
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| id | doaj.art-bb7165d952e84531877f9b6a72e873ba |
| institution | Directory Open Access Journal |
| issn | 2079-3197 |
| language | English |
| last_indexed | 2024-03-10T12:03:08Z |
| publishDate | 2021-04-01 |
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| record_format | Article |
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| spelling | doaj.art-bb7165d952e84531877f9b6a72e873ba2023-11-21T16:47:25ZengMDPI AGComputation2079-31972021-04-01955010.3390/computation9050050Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable PorosityAssunta Andreozzi0Luca Brunese1Marcello Iasiello2Claudio Tucci3Giuseppe Peter Vanoli4Department of Industrial Engineering, University of Naples-Federico II, Piazzale Tecchio, 80, 80125 Napoli, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, ItalyDepartment of Industrial Engineering, University of Naples-Federico II, Piazzale Tecchio, 80, 80125 Napoli, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, ItalyThermal ablation is a minimally or noninvasive cancer therapy technique that involves fewer complications, shorter hospital stays, and fewer costs. In this paper, a thermal-ablation bioheat model for cancer treatment is numerically investigated, using a porous media-based model. The main objective is to evaluate the effects of a variable blood volume fraction in the tumoral tissue (i.e., the porosity), in order to develop a more realistic model. A modified local thermal nonequilibrium model (LTNE) is implemented including the water content vaporization in the two phases separately and introducing the variable porosity in the domain, described by a quadratic function changing from the core to the rim of the tumoral sphere. The equations are numerically solved employing the finite-element commercial code COMSOL Multiphysics. Results are compared with the results obtained employing two uniform porosity values (ε = 0.07 and ε = 0.23) in terms of coagulation zones at the end of the heating period, maximum temperatures reached in the domain, and temperature fields and they are presented for different blood vessels. The outcomes highlight how important is to predict coagulation zones achieved in thermal ablation accurately. In this way, indeed, incomplete ablation, tumor recurrence, or healthy tissue necrosis can be avoided, and medical protocols and devices can be improved.https://www.mdpi.com/2079-3197/9/5/50bioheat transferhyperthermiathermal ablationporous mediavariable porositynumerical simulations |
| spellingShingle | Assunta Andreozzi Luca Brunese Marcello Iasiello Claudio Tucci Giuseppe Peter Vanoli Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity Computation bioheat transfer hyperthermia thermal ablation porous media variable porosity numerical simulations |
| title | Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity |
| title_full | Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity |
| title_fullStr | Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity |
| title_full_unstemmed | Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity |
| title_short | Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity |
| title_sort | numerical investigation of a thermal ablation porous media based model for tumoral tissue with variable porosity |
| topic | bioheat transfer hyperthermia thermal ablation porous media variable porosity numerical simulations |
| url | https://www.mdpi.com/2079-3197/9/5/50 |
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