Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays
<p>Abstract</p> <p>Background</p> <p>There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-<b>g </b>Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).</p> <p>Methods</p> <...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-09-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/11/264 |
| _version_ | 1818564528937369600 |
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| author | Mwananyanda Lawrence Kilembe William Wendt Joyanna Mutemba Charles Gonzalez-Diaz Esteban Talati Naasha J Chomba Elwyn Allen Susan del Rio Carlos Blumberg Henry M |
| author_facet | Mwananyanda Lawrence Kilembe William Wendt Joyanna Mutemba Charles Gonzalez-Diaz Esteban Talati Naasha J Chomba Elwyn Allen Susan del Rio Carlos Blumberg Henry M |
| author_sort | Mwananyanda Lawrence |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-<b>g </b>Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).</p> <p>Methods</p> <p>A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia.</p> <p>Results</p> <p>A total of 596 subjects (298 couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR = 2.22, 95% CI 1.42- 3.46) and TSPOT (OR = 1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count ≥ 388 cells/μl was associated with a positive TST (OR = 1.76 95% CI 1.10-2.82) and QFT (OR = 1.71 95% CI 1.06-2.77) but not TSPOT (OR = 1.20 95% CI 0.74-1.94).</p> <p>Conclusions</p> <p>Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count < 388 cells/μl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals.</p> |
| first_indexed | 2024-12-14T01:30:06Z |
| format | Article |
| id | doaj.art-bb71d9f0408e460d91a7b00082f02356 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T01:30:06Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-bb71d9f0408e460d91a7b00082f023562022-12-21T23:22:04ZengBMCBMC Infectious Diseases1471-23342011-09-0111126410.1186/1471-2334-11-264Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assaysMwananyanda LawrenceKilembe WilliamWendt JoyannaMutemba CharlesGonzalez-Diaz EstebanTalati Naasha JChomba ElwynAllen Susandel Rio CarlosBlumberg Henry M<p>Abstract</p> <p>Background</p> <p>There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-<b>g </b>Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI).</p> <p>Methods</p> <p>A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia.</p> <p>Results</p> <p>A total of 596 subjects (298 couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR = 2.22, 95% CI 1.42- 3.46) and TSPOT (OR = 1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count ≥ 388 cells/μl was associated with a positive TST (OR = 1.76 95% CI 1.10-2.82) and QFT (OR = 1.71 95% CI 1.06-2.77) but not TSPOT (OR = 1.20 95% CI 0.74-1.94).</p> <p>Conclusions</p> <p>Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count < 388 cells/μl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals.</p>http://www.biomedcentral.com/1471-2334/11/264 |
| spellingShingle | Mwananyanda Lawrence Kilembe William Wendt Joyanna Mutemba Charles Gonzalez-Diaz Esteban Talati Naasha J Chomba Elwyn Allen Susan del Rio Carlos Blumberg Henry M Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays BMC Infectious Diseases |
| title | Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays |
| title_full | Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays |
| title_fullStr | Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays |
| title_full_unstemmed | Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays |
| title_short | Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays |
| title_sort | diagnosis of latent tuberculosis infection among hiv discordant partners using interferon gamma release assays |
| url | http://www.biomedcentral.com/1471-2334/11/264 |
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