Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression
The presence of reward deficits in major depressive disorder is associated with abnormal striatal function. However, differences in striatal whole-brain functional between recurrent depressive episode (RDE) and first-episode depression (FDE) have not been elucidated. Thirty-three patients with RDE,...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/12/1603 |
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| author | Jifei Sun Zhongming Du Yue Ma Chunlei Guo Shanshan Gao Yi Luo Qingyan Chen Yang Hong Xue Xiao Xue Yu Jiliang Fang |
| author_facet | Jifei Sun Zhongming Du Yue Ma Chunlei Guo Shanshan Gao Yi Luo Qingyan Chen Yang Hong Xue Xiao Xue Yu Jiliang Fang |
| author_sort | Jifei Sun |
| collection | DOAJ |
| description | The presence of reward deficits in major depressive disorder is associated with abnormal striatal function. However, differences in striatal whole-brain functional between recurrent depressive episode (RDE) and first-episode depression (FDE) have not been elucidated. Thirty-three patients with RDE, 27 with FDE, and 35 healthy controls (HCs) were recruited for this study. A seed-based functional connectivity (FC) method was used to analyze abnormalities in six predefined striatal subregion circuits among the three groups of subjects and to further explore the correlation between abnormal FC and clinical symptoms. The results revealed that compared with the FDE group, the RDE group showed higher FC of the striatal subregion with the left middle occipital gyrus, left orbital area of the middle frontal gyrus, and bilateral posterior cerebellar gyrus, while showing lower FC of the striatal subregion with the right thalamus, left inferior parietal lobule, left middle cingulate gyrus, right angular gyrus, right cerebellum anterior lobe, and right caudate nucleus. In the RDE group, the HAMD-17 scores were positively correlated with the FC between the left dorsal rostral putamen and the left cerebellum posterior lobe. This study provides new insights into understanding the specificity of striatal circuits in the RDE group. |
| first_indexed | 2024-03-09T17:16:32Z |
| format | Article |
| id | doaj.art-bb75105768a0429a9d1e969b6999091b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T17:16:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-bb75105768a0429a9d1e969b6999091b2023-11-24T13:38:33ZengMDPI AGBrain Sciences2076-34252022-11-011212160310.3390/brainsci12121603Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent DepressionJifei Sun0Zhongming Du1Yue Ma2Chunlei Guo3Shanshan Gao4Yi Luo5Qingyan Chen6Yang Hong7Xue Xiao8Xue Yu9Jiliang Fang10Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaBeijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, ChinaBeijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaThe presence of reward deficits in major depressive disorder is associated with abnormal striatal function. However, differences in striatal whole-brain functional between recurrent depressive episode (RDE) and first-episode depression (FDE) have not been elucidated. Thirty-three patients with RDE, 27 with FDE, and 35 healthy controls (HCs) were recruited for this study. A seed-based functional connectivity (FC) method was used to analyze abnormalities in six predefined striatal subregion circuits among the three groups of subjects and to further explore the correlation between abnormal FC and clinical symptoms. The results revealed that compared with the FDE group, the RDE group showed higher FC of the striatal subregion with the left middle occipital gyrus, left orbital area of the middle frontal gyrus, and bilateral posterior cerebellar gyrus, while showing lower FC of the striatal subregion with the right thalamus, left inferior parietal lobule, left middle cingulate gyrus, right angular gyrus, right cerebellum anterior lobe, and right caudate nucleus. In the RDE group, the HAMD-17 scores were positively correlated with the FC between the left dorsal rostral putamen and the left cerebellum posterior lobe. This study provides new insights into understanding the specificity of striatal circuits in the RDE group.https://www.mdpi.com/2076-3425/12/12/1603recurrent depressive episodefirst depressive episodefunctional connectivitystriatalrs-fMRI |
| spellingShingle | Jifei Sun Zhongming Du Yue Ma Chunlei Guo Shanshan Gao Yi Luo Qingyan Chen Yang Hong Xue Xiao Xue Yu Jiliang Fang Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression Brain Sciences recurrent depressive episode first depressive episode functional connectivity striatal rs-fMRI |
| title | Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression |
| title_full | Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression |
| title_fullStr | Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression |
| title_full_unstemmed | Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression |
| title_short | Characterization of Resting-State Striatal Differences in First-Episode Depression and Recurrent Depression |
| title_sort | characterization of resting state striatal differences in first episode depression and recurrent depression |
| topic | recurrent depressive episode first depressive episode functional connectivity striatal rs-fMRI |
| url | https://www.mdpi.com/2076-3425/12/12/1603 |
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