Functions of PDE3 Isoforms in Cardiac Muscle
Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2308-3425/5/1/10 |
| Summary: | Isoforms in the PDE3 family of cyclic nucleotide phosphodiesterases have important roles in cyclic nucleotide-mediated signalling in cardiac myocytes. These enzymes are targeted by inhibitors used to increase contractility in patients with heart failure, with a combination of beneficial and adverse effects on clinical outcomes. This review covers relevant aspects of the molecular biology of the isoforms that have been identified in cardiac myocytes; the roles of these enzymes in modulating cAMP-mediated signalling and the processes mediated thereby; and the potential for targeting these enzymes to improve the profile of clinical responses. |
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| ISSN: | 2308-3425 |