The Anti-Apoptotic Role of Berberine in Preimplantation Embryo In Vitro Development through Regulation of miRNA-21.

Traditional Chinese medicinal herbs containing berberine have been historically used to prevent miscarriage. Here, we investigated whether the anti-apoptotic effects of berberine on pre-implantation embryonic development are regulated by miRNA-21. Mouse pronuclear embryos were cultured in medium wit...

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Bibliographic Details
Main Authors: Chao Zhang, Ya-Ran Shi, Xiao-Ran Liu, Yong-Chun Cao, Di Zhen, Zi-Ye Jia, Jin-Qi Jiang, Jian-Hui Tian, Jian-Ming Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4456273?pdf=render