The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients
Background: Prolonged heart rate-corrected QT (QTc) interval may reflect po or prognosis of patients with type 2 diabetes (T2D). Serum adenosine deamina se (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammati on, which may participate in diabetic complications. We invest...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2021-08-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/aop/ec-21-0199/ec-21-0199.xml |
| _version_ | 1818461415481016320 |
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| author | Chun-feng Lu Xiao-qin Ge Yan Wang Jian-bin Su Xue-qin Wang Dong-mei Zhang Feng Xu Wang-shu Liu Min Su |
| author_facet | Chun-feng Lu Xiao-qin Ge Yan Wang Jian-bin Su Xue-qin Wang Dong-mei Zhang Feng Xu Wang-shu Liu Min Su |
| author_sort | Chun-feng Lu |
| collection | DOAJ |
| description | Background: Prolonged heart rate-corrected QT (QTc) interval may reflect po or prognosis of patients with type 2 diabetes (T2D). Serum adenosine deamina se (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammati on, which may participate in diabetic complications. We investigated the association of s erum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D.
Methods: In this cross-sectional study, a total of 492 patients with T2 D were recruited. Serum ADA levels were determined by venous blood during fasting . QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms.
Results: In this study, the prevalence of prolonged QTc interval was 22 .8%. Serum ADA levels were positively associated with QTc interval ( r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significan tly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in t he third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk fa ctors by multiple linear regression analysis, serum ADA level was still significantly ass ociated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379–10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290–13.860, P = 0.017) and ADA (OR 1.212, CI 1.094–1.343, P < 0.001) were independent contributors to prolonged QTc interval.
Conclusions: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D. |
| first_indexed | 2024-12-14T23:45:47Z |
| format | Article |
| id | doaj.art-bb7924a6843e4ef7808a5484eada8748 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T23:45:47Z |
| publishDate | 2021-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-bb7924a6843e4ef7808a5484eada87482022-12-21T22:43:24ZengBioscientificaEndocrine Connections2049-36142049-36142021-08-01108894901https://doi.org/10.1530/EC-21-0199The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patientsChun-feng Lu0Xiao-qin Ge1Yan Wang2Jian-bin Su3Xue-qin Wang4Dong-mei Zhang5Feng Xu6Wang-shu Liu7Min Su8Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Geriatrics, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaClinical Medicine Research Center, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, ChinaDepartment of Endocrinology, Nantong Hospital of Traditional Chinese Medicine, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, Nantong, ChinaBackground: Prolonged heart rate-corrected QT (QTc) interval may reflect po or prognosis of patients with type 2 diabetes (T2D). Serum adenosine deamina se (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammati on, which may participate in diabetic complications. We investigated the association of s erum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D. Methods: In this cross-sectional study, a total of 492 patients with T2 D were recruited. Serum ADA levels were determined by venous blood during fasting . QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms. Results: In this study, the prevalence of prolonged QTc interval was 22 .8%. Serum ADA levels were positively associated with QTc interval ( r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significan tly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in t he third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk fa ctors by multiple linear regression analysis, serum ADA level was still significantly ass ociated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379–10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290–13.860, P = 0.017) and ADA (OR 1.212, CI 1.094–1.343, P < 0.001) were independent contributors to prolonged QTc interval. Conclusions: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D.https://ec.bioscientifica.com/view/journals/ec/aop/ec-21-0199/ec-21-0199.xmltype 2 diabetesadenosine deaminaseqtc interval |
| spellingShingle | Chun-feng Lu Xiao-qin Ge Yan Wang Jian-bin Su Xue-qin Wang Dong-mei Zhang Feng Xu Wang-shu Liu Min Su The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients Endocrine Connections type 2 diabetes adenosine deaminase qtc interval |
| title | The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients |
| title_full | The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients |
| title_fullStr | The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients |
| title_full_unstemmed | The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients |
| title_short | The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients |
| title_sort | relationship between adenosine deaminase and heart rate corrected qt interval in type 2 diabetic patients |
| topic | type 2 diabetes adenosine deaminase qtc interval |
| url | https://ec.bioscientifica.com/view/journals/ec/aop/ec-21-0199/ec-21-0199.xml |
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