Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World
Novel insights in the development of a precision medicine approach for treating the neurodegenerative diseases (NDDs) are provided by emerging advances in the field of pharmacoepigenomics. In this context, microRNAs (miRNAs) have been extensively studied because of their implication in several disor...
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| Format: | Article |
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MDPI AG
2019-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/1/75 |
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| author | Nicoletta Nuzziello Loredana Ciaccia Maria Liguori |
| author_facet | Nicoletta Nuzziello Loredana Ciaccia Maria Liguori |
| author_sort | Nicoletta Nuzziello |
| collection | DOAJ |
| description | Novel insights in the development of a precision medicine approach for treating the neurodegenerative diseases (NDDs) are provided by emerging advances in the field of pharmacoepigenomics. In this context, microRNAs (miRNAs) have been extensively studied because of their implication in several disorders related to the central nervous system, as well as for their potential role as biomarkers of diagnosis, prognosis, and response to treatment. Recent studies in the field of neurodegeneration reported evidence that drug response and efficacy can be modulated by miRNA-mediated mechanisms. In fact, miRNAs seem to regulate the expression of pharmacology target genes, while approved (conventional and non-conventional) therapies can restore altered miRNAs observed in NDDs. The knowledge of miRNA pharmacoepigenomics may offers new clues to develop more effective treatments by providing novel insights into interindividual variability in drug disposition and response. Recently, the therapeutic potential of miRNAs is gaining increasing attention, and miRNA-based drugs (for cancer) have been under observation in clinical trials. However, the effective use of miRNAs as therapeutic target still needs to be investigated. Here, we report a brief review of representative studies in which miRNAs related to therapeutic effects have been investigated in NDDs, providing exciting potential prospects of miRNAs in pharmacoepigenomics and translational medicine. |
| first_indexed | 2024-03-12T19:21:13Z |
| format | Article |
| id | doaj.art-bb7ac4cfde8b46ad87ab345f787309e4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:21:13Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bb7ac4cfde8b46ad87ab345f787309e42023-08-02T05:08:57ZengMDPI AGCells2073-44092019-12-01917510.3390/cells9010075cells9010075Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ WorldNicoletta Nuzziello0Loredana Ciaccia1Maria Liguori2National Research Council, Institute of Biomedical Technologies, Bari Unit, 70126 Bari, ItalyDepartment of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalyNational Research Council, Institute of Biomedical Technologies, Bari Unit, 70126 Bari, ItalyNovel insights in the development of a precision medicine approach for treating the neurodegenerative diseases (NDDs) are provided by emerging advances in the field of pharmacoepigenomics. In this context, microRNAs (miRNAs) have been extensively studied because of their implication in several disorders related to the central nervous system, as well as for their potential role as biomarkers of diagnosis, prognosis, and response to treatment. Recent studies in the field of neurodegeneration reported evidence that drug response and efficacy can be modulated by miRNA-mediated mechanisms. In fact, miRNAs seem to regulate the expression of pharmacology target genes, while approved (conventional and non-conventional) therapies can restore altered miRNAs observed in NDDs. The knowledge of miRNA pharmacoepigenomics may offers new clues to develop more effective treatments by providing novel insights into interindividual variability in drug disposition and response. Recently, the therapeutic potential of miRNAs is gaining increasing attention, and miRNA-based drugs (for cancer) have been under observation in clinical trials. However, the effective use of miRNAs as therapeutic target still needs to be investigated. Here, we report a brief review of representative studies in which miRNAs related to therapeutic effects have been investigated in NDDs, providing exciting potential prospects of miRNAs in pharmacoepigenomics and translational medicine.https://www.mdpi.com/2073-4409/9/1/75micrornaneurodegenerative diseasesprecision medicinepharmacoepigenomicdrug responseepidrug |
| spellingShingle | Nicoletta Nuzziello Loredana Ciaccia Maria Liguori Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World Cells microrna neurodegenerative diseases precision medicine pharmacoepigenomic drug response epidrug |
| title | Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World |
| title_full | Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World |
| title_fullStr | Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World |
| title_full_unstemmed | Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World |
| title_short | Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World |
| title_sort | precision medicine in neurodegenerative diseases some promising tips coming from the micrornas world |
| topic | microrna neurodegenerative diseases precision medicine pharmacoepigenomic drug response epidrug |
| url | https://www.mdpi.com/2073-4409/9/1/75 |
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