Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes
Hepatocellular carcinoma is a disastrous cancer with an aberrant metabolism. In this study, we aimed to assess the role of metabolism in the prognosis of hepatocellular carcinoma. Ten metabolism-related pathways were identified to classify the hepatocellular carcinoma into two clusters: Metabolism_H...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.863266/full |
| _version_ | 1818552011044421632 |
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| author | Tingbo Ye Tingbo Ye Leilei Lin Lulu Cao Weiguo Huang Shengzhe Wei Yunfeng Shan Zhongjing Zhang |
| author_facet | Tingbo Ye Tingbo Ye Leilei Lin Lulu Cao Weiguo Huang Shengzhe Wei Yunfeng Shan Zhongjing Zhang |
| author_sort | Tingbo Ye |
| collection | DOAJ |
| description | Hepatocellular carcinoma is a disastrous cancer with an aberrant metabolism. In this study, we aimed to assess the role of metabolism in the prognosis of hepatocellular carcinoma. Ten metabolism-related pathways were identified to classify the hepatocellular carcinoma into two clusters: Metabolism_H and Metabolism_L. Compared with Metabolism_L, patients in Metabolism_H had lower survival rates with more mutated TP53 genes and more immune infiltration. Moreover, risk scores for predicting overall survival based on eleven differentially expressed metabolic genes were developed by the least absolute shrinkage and selection operator (LASSO)-Cox regression model in The Cancer Genome Atlas (TCGA) dataset, which was validated in the International Cancer Genome Consortium (ICGC) dataset. The immunohistochemistry staining of liver cancer patient specimens also identified that the 11 genes were associated with the prognosis of liver cancer patients. Multivariate Cox regression analyses indicated that the differentially expressed metabolic gene-based risk score was also an independent prognostic factor for overall survival. Furthermore, the risk score (AUC = 0.767) outperformed other clinical variables in predicting overall survival. Therefore, the metabolism-related survival-predictor model may predict overall survival excellently for HCC patients. |
| first_indexed | 2024-12-12T09:07:31Z |
| format | Article |
| id | doaj.art-bb7ae29bc4704f35953d5b4c9860abfd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T09:07:31Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bb7ae29bc4704f35953d5b4c9860abfd2022-12-22T00:29:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.863266863266Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway PhenotypesTingbo Ye0Tingbo Ye1Leilei Lin2Lulu Cao3Weiguo Huang4Shengzhe Wei5Yunfeng Shan6Zhongjing Zhang7Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Ultrasound, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Pathology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, ChinaDepartment of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaHepatocellular carcinoma is a disastrous cancer with an aberrant metabolism. In this study, we aimed to assess the role of metabolism in the prognosis of hepatocellular carcinoma. Ten metabolism-related pathways were identified to classify the hepatocellular carcinoma into two clusters: Metabolism_H and Metabolism_L. Compared with Metabolism_L, patients in Metabolism_H had lower survival rates with more mutated TP53 genes and more immune infiltration. Moreover, risk scores for predicting overall survival based on eleven differentially expressed metabolic genes were developed by the least absolute shrinkage and selection operator (LASSO)-Cox regression model in The Cancer Genome Atlas (TCGA) dataset, which was validated in the International Cancer Genome Consortium (ICGC) dataset. The immunohistochemistry staining of liver cancer patient specimens also identified that the 11 genes were associated with the prognosis of liver cancer patients. Multivariate Cox regression analyses indicated that the differentially expressed metabolic gene-based risk score was also an independent prognostic factor for overall survival. Furthermore, the risk score (AUC = 0.767) outperformed other clinical variables in predicting overall survival. Therefore, the metabolism-related survival-predictor model may predict overall survival excellently for HCC patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.863266/fullhepatocellular carcinomametabolismmutant oncogenetumor immunityoverall survival |
| spellingShingle | Tingbo Ye Tingbo Ye Leilei Lin Lulu Cao Weiguo Huang Shengzhe Wei Yunfeng Shan Zhongjing Zhang Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes Frontiers in Oncology hepatocellular carcinoma metabolism mutant oncogene tumor immunity overall survival |
| title | Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes |
| title_full | Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes |
| title_fullStr | Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes |
| title_full_unstemmed | Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes |
| title_short | Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes |
| title_sort | novel prognostic signatures of hepatocellular carcinoma based on metabolic pathway phenotypes |
| topic | hepatocellular carcinoma metabolism mutant oncogene tumor immunity overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.863266/full |
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