Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications
Crystalline iron boride (Fe2B) nanoparticles were successfully synthesized with magnesiothermic reduction reactions triggered by mechanochemical synthesis (MCS) and purified using selective hydrochloric (HCl) acid leaching. Various parameters of MCS were investigated in detail to optimize the synthe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217923000710 |
| _version_ | 1797737308793864192 |
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| author | Sıddıka Mertdinç-Ülküseven Farnoud Khakzad Caner Aslan Kubra Onbasli Çağdaş Çevik Sevim İşçi Özge Balcı-Çağıran Havva Yagci Acar M. Lütfi Öveçoğlu Duygu Ağaoğulları |
| author_facet | Sıddıka Mertdinç-Ülküseven Farnoud Khakzad Caner Aslan Kubra Onbasli Çağdaş Çevik Sevim İşçi Özge Balcı-Çağıran Havva Yagci Acar M. Lütfi Öveçoğlu Duygu Ağaoğulları |
| author_sort | Sıddıka Mertdinç-Ülküseven |
| collection | DOAJ |
| description | Crystalline iron boride (Fe2B) nanoparticles were successfully synthesized with magnesiothermic reduction reactions triggered by mechanochemical synthesis (MCS) and purified using selective hydrochloric (HCl) acid leaching. Various parameters of MCS were investigated in detail to optimize the synthesis conditions. First, Fe2O3/B/Mg powder mixtures were blended and milled for various durations (up to 8 h) using a high-energy ball mill until Fe2B formation was complete. For the milling optimization, two different ball-to-powder weight ratios (BPRs) were employed: 10/1 and 15/1. Different sizes of milling balls as MCS media were used to investigate their effects on the Fe2B formation. After the MCS experiments, powders were purified with a 4 M hydrochloric acid (HCl) solution to leach out the MgO by-product phase and to obtain pure Fe2B particles. Based on all the optimization studies, Fe2O3/B/Mg powders milled for 6 h using one φ 14.3 mm ball and five φ 12.4 mm balls with a 10/1 BPR and purified were selected as ideal products. Microstructural, thermal, rheological and magnetic properties were determined for the optimum Fe2B nanoparticles. This optimum batch comprising pure Fe2B nanoparticles (with an average size of 35 nm) was tested for biocompatibility (up to 72 h with 200 μg/mL) and specific absorption rate (SAR up to 55 °C) to evaluate its use in biomedical applications. The dose and time-dependent cytotoxicity of poly (acrylic acid) coated Fe2B nanoparticles (PAA-Fe2B) were investigated with cancerous HeLa, MCF7, A549 and MDA-MB-231 and healthy Vero E6 cells. PAA-Fe2B nanoparticles were found to be cytocompatible with Vero E6 cells, HeLa and MCF7 cancer cells. The SAR value of the Fe2B nanoparticles was determined as 9.15 W/g, so the synthesis mechanism and some properties of Fe2B nanoparticles were successfully proposed for possible biomedical applications. |
| first_indexed | 2024-03-12T13:27:47Z |
| format | Article |
| id | doaj.art-bb7d8ae9aa9d4e9caeeb6fb652d8c1c4 |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-03-12T13:27:47Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-bb7d8ae9aa9d4e9caeeb6fb652d8c1c42023-08-25T04:24:36ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792023-09-0183100602Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applicationsSıddıka Mertdinç-Ülküseven0Farnoud Khakzad1Caner Aslan2Kubra Onbasli3Çağdaş Çevik4Sevim İşçi5Özge Balcı-Çağıran6Havva Yagci Acar7M. Lütfi Öveçoğlu8Duygu Ağaoğulları9Istanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469, Maslak, Istanbul, Türkiye; Istanbul Technical University, Prof. Dr. Adnan Tekin Materials Science and Production Technologies Applied Research Center (ATARC), 34469, Maslak, Istanbul, Türkiye; Corresponding author. Istanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469 Maslak, Istanbul, Türkiye.Istanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469, Maslak, Istanbul, Türkiye; Istanbul Technical University, Prof. Dr. Adnan Tekin Materials Science and Production Technologies Applied Research Center (ATARC), 34469, Maslak, Istanbul, TürkiyeIstanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469, Maslak, Istanbul, TürkiyeIstanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, 34469, Maslak, Istanbul, TürkiyeIstanbul Technical University, Faculty of Science and Letters, Department of Physics, 34469, Maslak, Istanbul, TürkiyeIstanbul Technical University, Faculty of Science and Letters, Department of Physics, 34469, Maslak, Istanbul, TürkiyeKoç University, Department of Chemistry, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Türkiye; Koç University, Boron and Advanced Materials Application and Research Center (KUBAM), Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, TürkiyeKoç University, Department of Chemistry, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Türkiye; Koç University, Graduate School of Materials Science and Engineering, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Türkiye; Koç University, Surface Science and Technology Center (KUYTAM), Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, TürkiyeIstanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469, Maslak, Istanbul, TürkiyeIstanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469, Maslak, Istanbul, Türkiye; Istanbul Technical University, Prof. Dr. Adnan Tekin Materials Science and Production Technologies Applied Research Center (ATARC), 34469, Maslak, Istanbul, Türkiye; Corresponding author. Istanbul Technical University, Faculty of Chemical and Metallurgical Engineering, Metallurgical and Materials Engineering Department, Particulate Materials Laboratories (PML), Graphene & 2D Materials Laboratory, 34469 Maslak, Istanbul, Türkiye.Crystalline iron boride (Fe2B) nanoparticles were successfully synthesized with magnesiothermic reduction reactions triggered by mechanochemical synthesis (MCS) and purified using selective hydrochloric (HCl) acid leaching. Various parameters of MCS were investigated in detail to optimize the synthesis conditions. First, Fe2O3/B/Mg powder mixtures were blended and milled for various durations (up to 8 h) using a high-energy ball mill until Fe2B formation was complete. For the milling optimization, two different ball-to-powder weight ratios (BPRs) were employed: 10/1 and 15/1. Different sizes of milling balls as MCS media were used to investigate their effects on the Fe2B formation. After the MCS experiments, powders were purified with a 4 M hydrochloric acid (HCl) solution to leach out the MgO by-product phase and to obtain pure Fe2B particles. Based on all the optimization studies, Fe2O3/B/Mg powders milled for 6 h using one φ 14.3 mm ball and five φ 12.4 mm balls with a 10/1 BPR and purified were selected as ideal products. Microstructural, thermal, rheological and magnetic properties were determined for the optimum Fe2B nanoparticles. This optimum batch comprising pure Fe2B nanoparticles (with an average size of 35 nm) was tested for biocompatibility (up to 72 h with 200 μg/mL) and specific absorption rate (SAR up to 55 °C) to evaluate its use in biomedical applications. The dose and time-dependent cytotoxicity of poly (acrylic acid) coated Fe2B nanoparticles (PAA-Fe2B) were investigated with cancerous HeLa, MCF7, A549 and MDA-MB-231 and healthy Vero E6 cells. PAA-Fe2B nanoparticles were found to be cytocompatible with Vero E6 cells, HeLa and MCF7 cancer cells. The SAR value of the Fe2B nanoparticles was determined as 9.15 W/g, so the synthesis mechanism and some properties of Fe2B nanoparticles were successfully proposed for possible biomedical applications.http://www.sciencedirect.com/science/article/pii/S2468217923000710Iron borideMechanochemical synthesisMicrostructureMagnetic propertySpecific absorption rateCytotoxicity |
| spellingShingle | Sıddıka Mertdinç-Ülküseven Farnoud Khakzad Caner Aslan Kubra Onbasli Çağdaş Çevik Sevim İşçi Özge Balcı-Çağıran Havva Yagci Acar M. Lütfi Öveçoğlu Duygu Ağaoğulları Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications Journal of Science: Advanced Materials and Devices Iron boride Mechanochemical synthesis Microstructure Magnetic property Specific absorption rate Cytotoxicity |
| title | Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications |
| title_full | Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications |
| title_fullStr | Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications |
| title_full_unstemmed | Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications |
| title_short | Fe2B magnetic nanoparticles: Synthesis, optimization and cytotoxicity for potential biomedical applications |
| title_sort | fe2b magnetic nanoparticles synthesis optimization and cytotoxicity for potential biomedical applications |
| topic | Iron boride Mechanochemical synthesis Microstructure Magnetic property Specific absorption rate Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2468217923000710 |
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