Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review
Gastrointestinal stromal tumors (GISTs) are the main stromal tumors of the digestive tract. Extragastrointestinal stromal tumors (EGISTs) typically originate outside the gastrointestinal tract; are not associated with the stomach or intestinal walls; and are mainly derived from the mesentery, perito...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1038853/full |
| _version_ | 1811221358018822144 |
|---|---|
| author | Yuxuan Yang Yuxuan Yang Dengshun Sun Kun Tang Kun Tang |
| author_facet | Yuxuan Yang Yuxuan Yang Dengshun Sun Kun Tang Kun Tang |
| author_sort | Yuxuan Yang |
| collection | DOAJ |
| description | Gastrointestinal stromal tumors (GISTs) are the main stromal tumors of the digestive tract. Extragastrointestinal stromal tumors (EGISTs) typically originate outside the gastrointestinal tract; are not associated with the stomach or intestinal walls; and are mainly derived from the mesentery, peritoneum, posterior peritoneum, bladder, and scrotum. However, EGISTs from the prostate are rare. Here, we present a case of EGIST that passed off in the prostate of a 62-year-old man. The patient undergoes transrectal guided trans-perineal prostate puncture, and pathological reports suggest a GIST. Tumor cells are spindle-shaped, and no obvious neoplastic necrosis is seen in the sections. Immunohistochemical results are robustly positive for CD117, DOG-1, and CD34 expression. The patient had a good prognosis after treatment with imatinib, no recurrence and no metastases after six months of follow-up, and the prognosis was good. This article also provides a literature review and discussion of the treatment of EGISTs. |
| first_indexed | 2024-04-12T07:58:01Z |
| format | Article |
| id | doaj.art-bb7d9446f5c0446abe946c0c1cefc5e7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T07:58:01Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bb7d9446f5c0446abe946c0c1cefc5e72022-12-22T03:41:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10388531038853Primary extragastrointestinal stromal tumors of the prostate: A case report and literature reviewYuxuan Yang0Yuxuan Yang1Dengshun Sun2Kun Tang3Kun Tang4Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSecond Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSecond Clinical College, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGastrointestinal stromal tumors (GISTs) are the main stromal tumors of the digestive tract. Extragastrointestinal stromal tumors (EGISTs) typically originate outside the gastrointestinal tract; are not associated with the stomach or intestinal walls; and are mainly derived from the mesentery, peritoneum, posterior peritoneum, bladder, and scrotum. However, EGISTs from the prostate are rare. Here, we present a case of EGIST that passed off in the prostate of a 62-year-old man. The patient undergoes transrectal guided trans-perineal prostate puncture, and pathological reports suggest a GIST. Tumor cells are spindle-shaped, and no obvious neoplastic necrosis is seen in the sections. Immunohistochemical results are robustly positive for CD117, DOG-1, and CD34 expression. The patient had a good prognosis after treatment with imatinib, no recurrence and no metastases after six months of follow-up, and the prognosis was good. This article also provides a literature review and discussion of the treatment of EGISTs.https://www.frontiersin.org/articles/10.3389/fonc.2022.1038853/fullprostateextragastrointestinal stromal tumorsliterature reviewcase reportimatinib |
| spellingShingle | Yuxuan Yang Yuxuan Yang Dengshun Sun Kun Tang Kun Tang Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review Frontiers in Oncology prostate extragastrointestinal stromal tumors literature review case report imatinib |
| title | Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review |
| title_full | Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review |
| title_fullStr | Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review |
| title_full_unstemmed | Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review |
| title_short | Primary extragastrointestinal stromal tumors of the prostate: A case report and literature review |
| title_sort | primary extragastrointestinal stromal tumors of the prostate a case report and literature review |
| topic | prostate extragastrointestinal stromal tumors literature review case report imatinib |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1038853/full |
| work_keys_str_mv | AT yuxuanyang primaryextragastrointestinalstromaltumorsoftheprostateacasereportandliteraturereview AT yuxuanyang primaryextragastrointestinalstromaltumorsoftheprostateacasereportandliteraturereview AT dengshunsun primaryextragastrointestinalstromaltumorsoftheprostateacasereportandliteraturereview AT kuntang primaryextragastrointestinalstromaltumorsoftheprostateacasereportandliteraturereview AT kuntang primaryextragastrointestinalstromaltumorsoftheprostateacasereportandliteraturereview |