The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population
Objectives: To evaluate the efficacy and safety of dexamethasone (DEX) implants as mono or combination therapy for macular edema in retinal vein occlusion (RVO) with real-life conditions, and to detect factors that influence final visual acuity. Materials and Methods: Twenty-five eyes with macular...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2017-12-01
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| Series: | Türk Oftalmoloji Dergisi |
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| Online Access: | http://www.oftalmoloji.org/archives/archive-detail/article-preview/the-efficacy-and-safety-of-ntravitreal-dexamethasone-mplant-for--the-treatment-of-macular-edema-related-to-retinal-vein-occlusion-real-life-data-and-prognostic-factors-in-a-turkish-population/16474 |
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| author | Ayşe Yağmur Kanra Aylin Ardagil Akçakaya Sevil Arı Yaylalı Meltem Güzin Altınel Neslihan Sevimli |
| author_facet | Ayşe Yağmur Kanra Aylin Ardagil Akçakaya Sevil Arı Yaylalı Meltem Güzin Altınel Neslihan Sevimli |
| author_sort | Ayşe Yağmur Kanra |
| collection | DOAJ |
| description | Objectives: To evaluate the efficacy and safety of dexamethasone (DEX) implants as mono or combination therapy for macular edema in retinal vein occlusion (RVO) with real-life conditions, and to detect factors that influence final visual acuity.
Materials and Methods: Twenty-five eyes with macular edema secondary to RVO underwent assessments for central macular thickness (CMT), best-corrected visual acuity (BCVA), adverse events, and also morphologic changes in optical coherence tomography at an interval of 4-8 weeks after at least one DEX implant.
Results: Seventeen eyes with branch RVO and 8 eyes with central RVO were eligible for the study. The mean follow-up duration was 17 months (range, 12-26 months). Both mean BCVA (p=0.009) and CMT (p=0.006) improved significantly, and visual gains of ≥3 lines were achieved in 32% and ≥2 lines in 52% at the end of the follow-up period. The most powerful individual predictor of final visual acuity was baseline BCVA (r2=0.611, p<0.001, stepwise multiple regression), but the most efficient model was the combination of the ellipsoid zone (EZ) integrity and baseline BCVA (r2=0.766, p<0.001, stepwise multiple regression). Complication rates were very low after repeated DEX implants.
Conclusion: DEX implant seems to be an effective and safe treatment for macular edema in RVO despite negative real-life factors, and visual outcomes are associated with baseline visual acuity and EZ integrity. |
| first_indexed | 2024-04-10T10:19:17Z |
| format | Article |
| id | doaj.art-bb7db8b4139f4e3a842cdfb24f5545ca |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T10:19:17Z |
| publishDate | 2017-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-bb7db8b4139f4e3a842cdfb24f5545ca2023-02-15T16:21:42ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612017-12-0147633133710.4274/tjo.75317The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish PopulationAyşe Yağmur Kanra0Aylin Ardagil Akçakaya1Sevil Arı Yaylalı2Meltem Güzin Altınel3Neslihan Sevimli4University of Health Sciences, Ümraniye Training and Research Hospital, Department of Ophthalmology, İstanbul, TurkeyMedeniyet University, Göztepe Training and Research Hospital, Department of Ophthalmology, İstanbul, TurkeyMedeniyet University, Göztepe Training and Research Hospital, Department of Ophthalmology, İstanbul, TurkeyUniversity of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Ophthalmology, İstanbul, TurkeySultanbeyli State Hospital, Ophthalmology Clinic, İstanbul, TurkeyObjectives: To evaluate the efficacy and safety of dexamethasone (DEX) implants as mono or combination therapy for macular edema in retinal vein occlusion (RVO) with real-life conditions, and to detect factors that influence final visual acuity. Materials and Methods: Twenty-five eyes with macular edema secondary to RVO underwent assessments for central macular thickness (CMT), best-corrected visual acuity (BCVA), adverse events, and also morphologic changes in optical coherence tomography at an interval of 4-8 weeks after at least one DEX implant. Results: Seventeen eyes with branch RVO and 8 eyes with central RVO were eligible for the study. The mean follow-up duration was 17 months (range, 12-26 months). Both mean BCVA (p=0.009) and CMT (p=0.006) improved significantly, and visual gains of ≥3 lines were achieved in 32% and ≥2 lines in 52% at the end of the follow-up period. The most powerful individual predictor of final visual acuity was baseline BCVA (r2=0.611, p<0.001, stepwise multiple regression), but the most efficient model was the combination of the ellipsoid zone (EZ) integrity and baseline BCVA (r2=0.766, p<0.001, stepwise multiple regression). Complication rates were very low after repeated DEX implants. Conclusion: DEX implant seems to be an effective and safe treatment for macular edema in RVO despite negative real-life factors, and visual outcomes are associated with baseline visual acuity and EZ integrity.http://www.oftalmoloji.org/archives/archive-detail/article-preview/the-efficacy-and-safety-of-ntravitreal-dexamethasone-mplant-for--the-treatment-of-macular-edema-related-to-retinal-vein-occlusion-real-life-data-and-prognostic-factors-in-a-turkish-population/16474Anti-vascular endothelial growth factorintravitreal dexamethasone implantmacular edemaretinal vein occlusion |
| spellingShingle | Ayşe Yağmur Kanra Aylin Ardagil Akçakaya Sevil Arı Yaylalı Meltem Güzin Altınel Neslihan Sevimli The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population Türk Oftalmoloji Dergisi Anti-vascular endothelial growth factor intravitreal dexamethasone implant macular edema retinal vein occlusion |
| title | The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population |
| title_full | The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population |
| title_fullStr | The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population |
| title_full_unstemmed | The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population |
| title_short | The Efficacy and Safety of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Related to Retinal Vein Occlusion: Real-life Data and Prognostic Factors in a Turkish Population |
| title_sort | efficacy and safety of intravitreal dexamethasone implant for the treatment of macular edema related to retinal vein occlusion real life data and prognostic factors in a turkish population |
| topic | Anti-vascular endothelial growth factor intravitreal dexamethasone implant macular edema retinal vein occlusion |
| url | http://www.oftalmoloji.org/archives/archive-detail/article-preview/the-efficacy-and-safety-of-ntravitreal-dexamethasone-mplant-for--the-treatment-of-macular-edema-related-to-retinal-vein-occlusion-real-life-data-and-prognostic-factors-in-a-turkish-population/16474 |
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