Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells.

Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells.

Greater than 75% of all hematologic malignancies derive from germinal center (GC) or post-GC B cells, suggesting that the GC reaction predisposes B cells to tumorigenesis. Because GC B cells acquire expression of the highly mutagenic enzyme activation-induced cytidine deaminase (AID), GC B cells may...

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Bibliographic Details
Main Authors: Xiaosheng Wu, Renee C Tschumper, Albert Gutierrez, Stephen A Mihalcik, Grzegorz S Nowakowski, Diane F Jelinek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3002972?pdf=render

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http://europepmc.org/articles/PMC3002972?pdf=render

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