Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymph...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2015-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015005050179&lng=en&tlng=en |
| _version_ | 1819092259611607040 |
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| author | Karen Cecília de Lima Torres Natália Pessoa Rocha Vítor Bortolo de Rezende Walderez Ornelas Dutra Kenneth John Gollob Francisco Cardoso Antonio Lucio Teixeira |
| author_facet | Karen Cecília de Lima Torres Natália Pessoa Rocha Vítor Bortolo de Rezende Walderez Ornelas Dutra Kenneth John Gollob Francisco Cardoso Antonio Lucio Teixeira |
| author_sort | Karen Cecília de Lima Torres |
| collection | DOAJ |
| description | The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC. |
| first_indexed | 2024-12-21T22:52:47Z |
| format | Article |
| id | doaj.art-bb7eefee579d48b4af8630a8079e80d6 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-21T22:52:47Z |
| publishDate | 2015-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-bb7eefee579d48b4af8630a8079e80d62022-12-21T18:47:32ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-01-0100010.1590/0004-282X20150179S0004-282X2015005050179Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunctionKaren Cecília de Lima TorresNatália Pessoa RochaVítor Bortolo de RezendeWalderez Ornelas DutraKenneth John GollobFrancisco CardosoAntonio Lucio TeixeiraThe mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015005050179&lng=en&tlng=encoreia de Sydenhamautoimunidadelinfócitoscélulas B1 |
| spellingShingle | Karen Cecília de Lima Torres Natália Pessoa Rocha Vítor Bortolo de Rezende Walderez Ornelas Dutra Kenneth John Gollob Francisco Cardoso Antonio Lucio Teixeira Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction Arquivos de Neuro-Psiquiatria coreia de Sydenham autoimunidade linfócitos células B1 |
| title | Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction |
| title_full | Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction |
| title_fullStr | Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction |
| title_full_unstemmed | Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction |
| title_short | Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction |
| title_sort | persistent sydenham s chorea is not associated with sustained lymphocyte dysfunction |
| topic | coreia de Sydenham autoimunidade linfócitos células B1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015005050179&lng=en&tlng=en |
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