Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel

Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel

Abstract Lipid nanodiscs have become a standard tool for studying membrane proteins, including using single particle cryo-electron microscopy (cryo-EM). We find that reconstituting the pentameric ligand-gated ion channel (pLGIC), Erwinia ligand-gated ion channel (ELIC), in different nanodiscs produc...

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Bibliographic Details
Main Authors: Vikram Dalal, Mark J. Arcario, John T. Petroff, Brandon K. Tan, Noah M. Dietzen, Michael J. Rau, James A. J. Fitzpatrick, Grace Brannigan, Wayland W. L. Cheng
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44366-w

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