W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro
Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75–105 GHz) millim...
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MDPI AG
2020-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/14/4813 |
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| author | Konstantin Komoshvili Katya Israel Jacob Levitan Asher Yahalom Ayan Barbora Stella Liberman-Aronov |
| author_facet | Konstantin Komoshvili Katya Israel Jacob Levitan Asher Yahalom Ayan Barbora Stella Liberman-Aronov |
| author_sort | Konstantin Komoshvili |
| collection | DOAJ |
| description | Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75–105 GHz) millimeter waves (MMW) at 0.2 mW/cm<sup>2</sup> (2 W/m<sup>2</sup>). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 min duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 min of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation affected nuclear morphology of H1299 cells only and not of the immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers. |
| first_indexed | 2024-03-10T18:30:54Z |
| format | Article |
| id | doaj.art-bb81f31f174b442bbdf9cee0243be776 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T18:30:54Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-bb81f31f174b442bbdf9cee0243be7762023-11-20T06:40:20ZengMDPI AGApplied Sciences2076-34172020-07-011014481310.3390/app10144813W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In VitroKonstantin Komoshvili0Katya Israel1Jacob Levitan2Asher Yahalom3Ayan Barbora4Stella Liberman-Aronov5Department of Physics, Ariel University, Ariel 40700, IsraelDepartment of Molecular Biology, Ariel University, Ariel 40700, IsraelDepartment of Physics, Ariel University, Ariel 40700, IsraelDepartment of Electrical & Electronic Engineering, Ariel University, Ariel 40700, IsraelDepartment of Physics, Ariel University, Ariel 40700, IsraelDepartment of Molecular Biology, Ariel University, Ariel 40700, IsraelTherapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75–105 GHz) millimeter waves (MMW) at 0.2 mW/cm<sup>2</sup> (2 W/m<sup>2</sup>). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 min duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 min of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation affected nuclear morphology of H1299 cells only and not of the immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers.https://www.mdpi.com/2076-3417/10/14/4813W-band (75–105 GHz) MMWH1299 human lung cancer cellsnon-tumorigenic MCF-10A human epithelial cellsin vitro |
| spellingShingle | Konstantin Komoshvili Katya Israel Jacob Levitan Asher Yahalom Ayan Barbora Stella Liberman-Aronov W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro Applied Sciences W-band (75–105 GHz) MMW H1299 human lung cancer cells non-tumorigenic MCF-10A human epithelial cells in vitro |
| title | W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro |
| title_full | W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro |
| title_fullStr | W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro |
| title_full_unstemmed | W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro |
| title_short | W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-Tumorigenic MCF-10A Human Epithelial Cells In Vitro |
| title_sort | w band millimeter waves targeted mortality of h1299 human lung cancer cells without affecting non tumorigenic mcf 10a human epithelial cells in vitro |
| topic | W-band (75–105 GHz) MMW H1299 human lung cancer cells non-tumorigenic MCF-10A human epithelial cells in vitro |
| url | https://www.mdpi.com/2076-3417/10/14/4813 |
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