Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults
Abstract Background Hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD). However, there is limited evidence on the relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity. Our aim...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12986-020-00483-7 |
| _version_ | 1819202616404475904 |
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| author | Yun Qiu Qi Zhao Na Wang Yuting Yu Ruiping Wang Yue Zhang Shuheng Cui Meiying Zhu Xing Liu Yonggen Jiang Genming Zhao |
| author_facet | Yun Qiu Qi Zhao Na Wang Yuting Yu Ruiping Wang Yue Zhang Shuheng Cui Meiying Zhu Xing Liu Yonggen Jiang Genming Zhao |
| author_sort | Yun Qiu |
| collection | DOAJ |
| description | Abstract Background Hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD). However, there is limited evidence on the relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity. Our aim was to explore the associations of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults. Methods A population-based, cross-sectional study was conducted among Chinese participants aged 20–74 years from June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as decreased eGFR. HTGW phenotype was defined as triglyceride (TG) ≥1.7 mmol/L and a waist circumference (WC) of ≥90 cm for men and ≥ 80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models. Results A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW) and elevated TG level/enlarged WC (HTGW) phenotypes were associated with the increased risk of decreased eGFR. Multivariable-adjusted ORs (95% CI) associated with NTGW, elevated TG level/normal WC (HTNW), and HTGW phenotypes were 1.75 (1.41–2.18), 1.29 (0.99–1.68), and 1.99 (1.54–2.58), respectively. These associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. HTGW phenotype was consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk. Conclusions HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages, except for severely decreased eGFR. Further prospective studies are warranted to confirm our findings and to investigate the underlying biological mechanisms. |
| first_indexed | 2024-12-23T04:06:51Z |
| format | Article |
| id | doaj.art-bb82d4e2bbd24230aef6459dc3aa815b |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-23T04:06:51Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-bb82d4e2bbd24230aef6459dc3aa815b2022-12-21T18:00:37ZengBMCNutrition & Metabolism1743-70752020-08-0117111010.1186/s12986-020-00483-7Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adultsYun Qiu0Qi Zhao1Na Wang2Yuting Yu3Ruiping Wang4Yue Zhang5Shuheng Cui6Meiying Zhu7Xing Liu8Yonggen Jiang9Genming Zhao10Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversitySongjiang District Center for Disease Control and PreventionDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversitySongjiang District Center for Disease Control and PreventionDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversitySongjiang District Center for Disease Control and PreventionDepartment of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan UniversityAbstract Background Hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD). However, there is limited evidence on the relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity. Our aim was to explore the associations of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults. Methods A population-based, cross-sectional study was conducted among Chinese participants aged 20–74 years from June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as decreased eGFR. HTGW phenotype was defined as triglyceride (TG) ≥1.7 mmol/L and a waist circumference (WC) of ≥90 cm for men and ≥ 80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models. Results A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW) and elevated TG level/enlarged WC (HTGW) phenotypes were associated with the increased risk of decreased eGFR. Multivariable-adjusted ORs (95% CI) associated with NTGW, elevated TG level/normal WC (HTNW), and HTGW phenotypes were 1.75 (1.41–2.18), 1.29 (0.99–1.68), and 1.99 (1.54–2.58), respectively. These associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. HTGW phenotype was consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk. Conclusions HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages, except for severely decreased eGFR. Further prospective studies are warranted to confirm our findings and to investigate the underlying biological mechanisms.http://link.springer.com/article/10.1186/s12986-020-00483-7Chronic kidney diseaseEstimated glomerular filtration rateHypertriglyceridemic waist phenotypeRenal function decline |
| spellingShingle | Yun Qiu Qi Zhao Na Wang Yuting Yu Ruiping Wang Yue Zhang Shuheng Cui Meiying Zhu Xing Liu Yonggen Jiang Genming Zhao Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults Nutrition & Metabolism Chronic kidney disease Estimated glomerular filtration rate Hypertriglyceridemic waist phenotype Renal function decline |
| title | Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults |
| title_full | Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults |
| title_fullStr | Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults |
| title_full_unstemmed | Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults |
| title_short | Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults |
| title_sort | association of hypertriglyceridemic waist phenotype with renal function impairment a cross sectional study in a population of chinese adults |
| topic | Chronic kidney disease Estimated glomerular filtration rate Hypertriglyceridemic waist phenotype Renal function decline |
| url | http://link.springer.com/article/10.1186/s12986-020-00483-7 |
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