Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults
Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/4/1115 |
| _version_ | 1797570431363842048 |
|---|---|
| author | Mariana O. C. Coelho Alistair J. Monteyne Ishara D. Kamalanathan Vesna Najdanovic-Visak Tim J. A. Finnigan Francis B. Stephens Benjamin T. Wall |
| author_facet | Mariana O. C. Coelho Alistair J. Monteyne Ishara D. Kamalanathan Vesna Najdanovic-Visak Tim J. A. Finnigan Francis B. Stephens Benjamin T. Wall |
| author_sort | Mariana O. C. Coelho |
| collection | DOAJ |
| description | Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive state and throughout a 24 h postprandial period, and were used to determine circulating uric acid, glucose, and insulin concentrations. Mixed meal ingestion had divergent effects on serum uric acid concentrations across conditions (time x condition interaction; <i>P</i> < 0.001), with L-NU decreasing transiently (from 45 to 240 min postprandially) by ~7% (from 279 ± 16 to 257 ± 14 µmol·L<sup>−1</sup>) and H-NU resulting in a ~12% increase (from 284 ± 13 to 319 ± 12 µmol·L<sup>−1</sup> after 210 min), remaining elevated for 12 h and returning to baseline concentrations after 24 h. There were no differences between conditions in blood glucose or serum insulin responses, nor in indices of insulin sensitivity. The ingestion of a nucleotide-rich mixed-meal increases serum uric acid concentrations for ~12 h, but does not influence postprandial blood glucose or serum insulin concentrations. |
| first_indexed | 2024-03-10T20:25:27Z |
| format | Article |
| id | doaj.art-bb841c333dcf4b29af393c55a4e48a7e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:25:27Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bb841c333dcf4b29af393c55a4e48a7e2023-11-19T21:52:33ZengMDPI AGNutrients2072-66432020-04-01124111510.3390/nu12041115Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young AdultsMariana O. C. Coelho0Alistair J. Monteyne1Ishara D. Kamalanathan2Vesna Najdanovic-Visak3Tim J. A. Finnigan4Francis B. Stephens5Benjamin T. Wall6Department of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UKDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UKUK Research and Innovation, Polaris House, Swindon SN2 1FL, UKChemical Engineering and Applied Chemistry (CEAC), Energy and Bioproducts Research Institute (EBRI), Aston University, Birmingham B4 7ET, UKMarlow Foods Ltd., Stokesley TS9 7AB, UKDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UKDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, UKCirculating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive state and throughout a 24 h postprandial period, and were used to determine circulating uric acid, glucose, and insulin concentrations. Mixed meal ingestion had divergent effects on serum uric acid concentrations across conditions (time x condition interaction; <i>P</i> < 0.001), with L-NU decreasing transiently (from 45 to 240 min postprandially) by ~7% (from 279 ± 16 to 257 ± 14 µmol·L<sup>−1</sup>) and H-NU resulting in a ~12% increase (from 284 ± 13 to 319 ± 12 µmol·L<sup>−1</sup> after 210 min), remaining elevated for 12 h and returning to baseline concentrations after 24 h. There were no differences between conditions in blood glucose or serum insulin responses, nor in indices of insulin sensitivity. The ingestion of a nucleotide-rich mixed-meal increases serum uric acid concentrations for ~12 h, but does not influence postprandial blood glucose or serum insulin concentrations.https://www.mdpi.com/2072-6643/12/4/1115nucleotidesserum uric acidmetabolic healthmycoprotein |
| spellingShingle | Mariana O. C. Coelho Alistair J. Monteyne Ishara D. Kamalanathan Vesna Najdanovic-Visak Tim J. A. Finnigan Francis B. Stephens Benjamin T. Wall Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults Nutrients nucleotides serum uric acid metabolic health mycoprotein |
| title | Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults |
| title_full | Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults |
| title_fullStr | Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults |
| title_full_unstemmed | Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults |
| title_short | Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults |
| title_sort | short communication ingestion of a nucleotide rich mixed meal increases serum uric acid concentrations but does not affect postprandial blood glucose or serum insulin responses in young adults |
| topic | nucleotides serum uric acid metabolic health mycoprotein |
| url | https://www.mdpi.com/2072-6643/12/4/1115 |
| work_keys_str_mv | AT marianaoccoelho shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT alistairjmonteyne shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT isharadkamalanathan shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT vesnanajdanovicvisak shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT timjafinnigan shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT francisbstephens shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults AT benjamintwall shortcommunicationingestionofanucleotiderichmixedmealincreasesserumuricacidconcentrationsbutdoesnotaffectpostprandialbloodglucoseorseruminsulinresponsesinyoungadults |