Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
Release of α-synuclein aggregates by neurons instigates spread of pathology in synucleinopathies, but the mechanism remains unclear. Here the authors show that neuronally generated α-synuclein aggregates accumulate within neuronal lysosomes and are released via SNARE-dependent lysosomal exocytosis....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32625-1 |
| _version_ | 1818082240379224064 |
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| author | Ying Xue Xie Nima N. Naseri Jasmine Fels Parinati Kharel Yoonmi Na Diane Lane Jacqueline Burré Manu Sharma |
| author_facet | Ying Xue Xie Nima N. Naseri Jasmine Fels Parinati Kharel Yoonmi Na Diane Lane Jacqueline Burré Manu Sharma |
| author_sort | Ying Xue Xie |
| collection | DOAJ |
| description | Release of α-synuclein aggregates by neurons instigates spread of pathology in synucleinopathies, but the mechanism remains unclear. Here the authors show that neuronally generated α-synuclein aggregates accumulate within neuronal lysosomes and are released via SNARE-dependent lysosomal exocytosis. |
| first_indexed | 2024-12-10T19:18:57Z |
| format | Article |
| id | doaj.art-bb879c277162488aa71514ea44aa89e5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T19:18:57Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bb879c277162488aa71514ea44aa89e52022-12-22T01:36:32ZengNature PortfolioNature Communications2041-17232022-08-0113111610.1038/s41467-022-32625-1Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy modelsYing Xue Xie0Nima N. Naseri1Jasmine Fels2Parinati Kharel3Yoonmi Na4Diane Lane5Jacqueline Burré6Manu Sharma7Appel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineDepartment of Chemistry, University of PennsylvaniaAppel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineAppel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineAppel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineFeil Family Brain & Mind Research Institute, Weill Cornell MedicineAppel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineAppel Institute for Alzheimer’s Research, and Feil Family Brain & Mind Research Institute, Weill Cornell MedicineRelease of α-synuclein aggregates by neurons instigates spread of pathology in synucleinopathies, but the mechanism remains unclear. Here the authors show that neuronally generated α-synuclein aggregates accumulate within neuronal lysosomes and are released via SNARE-dependent lysosomal exocytosis.https://doi.org/10.1038/s41467-022-32625-1 |
| spellingShingle | Ying Xue Xie Nima N. Naseri Jasmine Fels Parinati Kharel Yoonmi Na Diane Lane Jacqueline Burré Manu Sharma Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models Nature Communications |
| title | Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models |
| title_full | Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models |
| title_fullStr | Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models |
| title_full_unstemmed | Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models |
| title_short | Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models |
| title_sort | lysosomal exocytosis releases pathogenic α synuclein species from neurons in synucleinopathy models |
| url | https://doi.org/10.1038/s41467-022-32625-1 |
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