Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

Inhibition of DNA Repair Pathways and Induction of ROS Are Potential Mechanisms of Action of the Small Molecule Inhibitor BOLD-100 in Breast Cancer

BOLD-100, a ruthenium-based complex, sodium trans-[tetrachloridobis (1H-indazole) ruthenate (III)] (also known as IT-139, NKP1339 or KP1339), is a novel small molecule drug that demonstrated a manageable safety profile at the maximum tolerated dose and modest antitumor activity in a phase I clinical...

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Bibliographic Details
Main Authors: Suzanne Bakewell, Isabel Conde, Yassi Fallah, Mathew McCoy, Lu Jin, Ayesha N. Shajahan-Haq
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
breast cancer
BOLD-100
olaparib
triple negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/12/9/2647

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