Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock
The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospec...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2090 |
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| author | Jong Eun Park Tae Gun Shin Daun Jeong Gun Tak Lee Seung Mok Ryoo Won Young Kim You Hwan Jo Gil Joon Suh Sung Yeon Hwang |
| author_facet | Jong Eun Park Tae Gun Shin Daun Jeong Gun Tak Lee Seung Mok Ryoo Won Young Kim You Hwan Jo Gil Joon Suh Sung Yeon Hwang |
| author_sort | Jong Eun Park |
| collection | DOAJ |
| description | The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11.4 mmol/L. Multivariable Cox regression analysis was performed to examine the association between vitamin C levels and 28-day mortality. A total of 165 patients was included for analysis and 77 (46.7%) had vitamin C deficiency. There was no significant difference in the 28-day mortality rate between the vitamin C deficiency group and the normal group (23.4% (<i>n</i> = 18/77) vs. 13.6% (<i>n</i> = 12/88), <i>p</i> = 0.083). Multivariable Cox proportional hazard analysis showed vitamin C deficiency to be associated with increased risk of 28-day mortality (adjusted hazard ratio, 2.65, 95% confidence interval (CI), 1.08–6.45; <i>p</i> = 0.032). Initial vitamin C deficiency was associated with a higher risk of 28-day mortality in patients with septic shock after adjusting for intravenous administration of vitamin C and thiamine, baseline characteristics, laboratory findings, and severity of illness. |
| first_indexed | 2024-03-10T00:40:37Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:40:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-bb8a998f88de41d1935c718b81c4b6ff2023-11-23T15:08:58ZengMDPI AGBiomedicines2227-90592022-08-01109209010.3390/biomedicines10092090Association between Vitamin C Deficiency and Mortality in Patients with Septic ShockJong Eun Park0Tae Gun Shin1Daun Jeong2Gun Tak Lee3Seung Mok Ryoo4Won Young Kim5You Hwan Jo6Gil Joon Suh7Sung Yeon Hwang8Department of Emergency Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, KoreaDepartment of Emergency Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, KoreaDepartment of Emergency Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, KoreaDepartment of Emergency Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, KoreaDepartment of Emergency Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, KoreaDepartment of Emergency Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 05505, KoreaDepartment of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Emergency Medicine, College of Medicine, Seoul National University, Seoul 03080, KoreaDepartment of Emergency Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, KoreaThe prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11.4 mmol/L. Multivariable Cox regression analysis was performed to examine the association between vitamin C levels and 28-day mortality. A total of 165 patients was included for analysis and 77 (46.7%) had vitamin C deficiency. There was no significant difference in the 28-day mortality rate between the vitamin C deficiency group and the normal group (23.4% (<i>n</i> = 18/77) vs. 13.6% (<i>n</i> = 12/88), <i>p</i> = 0.083). Multivariable Cox proportional hazard analysis showed vitamin C deficiency to be associated with increased risk of 28-day mortality (adjusted hazard ratio, 2.65, 95% confidence interval (CI), 1.08–6.45; <i>p</i> = 0.032). Initial vitamin C deficiency was associated with a higher risk of 28-day mortality in patients with septic shock after adjusting for intravenous administration of vitamin C and thiamine, baseline characteristics, laboratory findings, and severity of illness.https://www.mdpi.com/2227-9059/10/9/2090sepsisseptic shockascorbic acidmortality |
| spellingShingle | Jong Eun Park Tae Gun Shin Daun Jeong Gun Tak Lee Seung Mok Ryoo Won Young Kim You Hwan Jo Gil Joon Suh Sung Yeon Hwang Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock Biomedicines sepsis septic shock ascorbic acid mortality |
| title | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock |
| title_full | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock |
| title_fullStr | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock |
| title_full_unstemmed | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock |
| title_short | Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock |
| title_sort | association between vitamin c deficiency and mortality in patients with septic shock |
| topic | sepsis septic shock ascorbic acid mortality |
| url | https://www.mdpi.com/2227-9059/10/9/2090 |
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