Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogram human somatic cells to a pluripotent embryonic stem cell-like state through the ectopic expression of a combination of...

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Bibliographic Details
Main Authors: Adekunle Ebenezer Omole, Adegbenro Omotuyi John Fakoya
Format: Article
Language:English
Published: PeerJ Inc. 2018-05-01
Series:PeerJ
Subjects:
Induced pluripotent stem cells
Reprogramming
Reprogramming factors
Embryonic stem cells
Gene editing technology
CRISPR
Online Access:https://peerj.com/articles/4370.pdf

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