Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder
Cranberry fruits are an important source of anthocyanins and anthocyanidins. The aim of the present study was to investigate the effect of excipients on the solubility of cranberry anthocyanins and their dissolution kinetics as well as on the disintegration time of the capsules. Selected excipients...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/6/1397 |
| _version_ | 1797609370983333888 |
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| author | Rima Šedbarė Valdimaras Janulis Kristina Ramanauskiene |
| author_facet | Rima Šedbarė Valdimaras Janulis Kristina Ramanauskiene |
| author_sort | Rima Šedbarė |
| collection | DOAJ |
| description | Cranberry fruits are an important source of anthocyanins and anthocyanidins. The aim of the present study was to investigate the effect of excipients on the solubility of cranberry anthocyanins and their dissolution kinetics as well as on the disintegration time of the capsules. Selected excipients (sodium carboxymethyl cellulose, beta-cyclodextrin and chitosan) were found to affect the solubility and release kinetics of anthocyanins in freeze-dried cranberry powder. Capsule formulations N1–N9 had a disintegration time of less than 10 min, and capsule formulation N10 containing 0.200 g of freeze-dried cranberry powder, 0.100 g of Prosolv (combination of microcrystalline cellulose and colloidal silicon dioxide), and 0.100 g of chitosan had a capsule disintegration time of over 30 min. The total amount of anthocyanins released into the acceptor medium ranged from 1.26 ± 0.06 mg to 1.56 ± 0.03 mg. Capsule dissolution test data showed that the time to release into the acceptor medium was statistically significantly longer for the chitosan-containing capsule formulations compared to the control capsules (<i>p</i> < 0.05). Freeze-dried cranberry fruit powder is a potential source of anthocyanin-rich dietary supplements, and the choice of excipient chitosan could be a suitable solution in capsule formulations providing greater anthocyanin stability and modified release in the gastrointestinal tract. |
| first_indexed | 2024-03-11T06:00:31Z |
| format | Article |
| id | doaj.art-bb8f0f8778004921bef227bc6ece22e9 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T06:00:31Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-bb8f0f8778004921bef227bc6ece22e92023-11-17T13:23:21ZengMDPI AGPlants2223-77472023-03-01126139710.3390/plants12061397Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit PowderRima Šedbarė0Valdimaras Janulis1Kristina Ramanauskiene2Department of Pharmacognosy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50162 Kaunas, LithuaniaDepartment of Pharmacognosy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50162 Kaunas, LithuaniaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50162 Kaunas, LithuaniaCranberry fruits are an important source of anthocyanins and anthocyanidins. The aim of the present study was to investigate the effect of excipients on the solubility of cranberry anthocyanins and their dissolution kinetics as well as on the disintegration time of the capsules. Selected excipients (sodium carboxymethyl cellulose, beta-cyclodextrin and chitosan) were found to affect the solubility and release kinetics of anthocyanins in freeze-dried cranberry powder. Capsule formulations N1–N9 had a disintegration time of less than 10 min, and capsule formulation N10 containing 0.200 g of freeze-dried cranberry powder, 0.100 g of Prosolv (combination of microcrystalline cellulose and colloidal silicon dioxide), and 0.100 g of chitosan had a capsule disintegration time of over 30 min. The total amount of anthocyanins released into the acceptor medium ranged from 1.26 ± 0.06 mg to 1.56 ± 0.03 mg. Capsule dissolution test data showed that the time to release into the acceptor medium was statistically significantly longer for the chitosan-containing capsule formulations compared to the control capsules (<i>p</i> < 0.05). Freeze-dried cranberry fruit powder is a potential source of anthocyanin-rich dietary supplements, and the choice of excipient chitosan could be a suitable solution in capsule formulations providing greater anthocyanin stability and modified release in the gastrointestinal tract.https://www.mdpi.com/2223-7747/12/6/1397<i>Vaccinium macrocarpon</i>food supplementUPLC-DADmodified-releasechitosan |
| spellingShingle | Rima Šedbarė Valdimaras Janulis Kristina Ramanauskiene Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder Plants <i>Vaccinium macrocarpon</i> food supplement UPLC-DAD modified-release chitosan |
| title | Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder |
| title_full | Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder |
| title_fullStr | Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder |
| title_full_unstemmed | Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder |
| title_short | Formulation and Biopharmaceutical Evaluation of Capsules Containing Freeze-Dried Cranberry Fruit Powder |
| title_sort | formulation and biopharmaceutical evaluation of capsules containing freeze dried cranberry fruit powder |
| topic | <i>Vaccinium macrocarpon</i> food supplement UPLC-DAD modified-release chitosan |
| url | https://www.mdpi.com/2223-7747/12/6/1397 |
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