Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda
Introduction. The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests. Methods. Among people living with and without HIV and att...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2023/6717854 |
| _version_ | 1811171050245849088 |
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| author | Clara Wekesa Rosalind Parkes-Ratanshi Gregory D. Kirk Ponsiano Ocama |
| author_facet | Clara Wekesa Rosalind Parkes-Ratanshi Gregory D. Kirk Ponsiano Ocama |
| author_sort | Clara Wekesa |
| collection | DOAJ |
| description | Introduction. The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests. Methods. Among people living with and without HIV and attending care, we used the R ratio to evaluate for liver injury patterns. Liver injury patterns were defined as cholestatic (R<2), mixed (R=2‐5), and hepatocellular (R>5). Results. Overall, the proportions of participants with cholestatic liver injury, mixed liver injury, and hepatocellular liver injury were 55%, 34%, and 4%, respectively, with similar distribution when stratified by HIV status. Alcohol use among participants without HIV was associated with all patterns of liver injury (cholestatic liver injury (OR=4.9 CI (1.0-24.2); p=0.054), mixed liver injury (OR=5.3 CI (1.1-27.3); p=0.043), and hepatocellular liver injury (OR=13.2 CI (1.0-167.3); p=0.046)). Increasing age was associated with cholestatic liver injury among participants with HIV (OR=2.3 CI (1.0-5.3); p=0.038). Despite a high hepatitis B prevalence among participants with HIV, there was no association with liver injury. Conclusions. Liver injury is prevalent among both people living with and without HIV in care, and cholestatic liver injury is the most common pattern. Alcohol is associated with all patterns of liver injury and increasing age associated with cholestatic liver injury among people living without HIV and people living with HIV, respectively. |
| first_indexed | 2024-04-10T17:07:41Z |
| format | Article |
| id | doaj.art-bb9064953ae84780a295c2427875b2de |
| institution | Directory Open Access Journal |
| issn | 2090-3456 |
| language | English |
| last_indexed | 2024-04-10T17:07:41Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj.art-bb9064953ae84780a295c2427875b2de2023-02-06T01:40:22ZengHindawi LimitedInternational Journal of Hepatology2090-34562023-01-01202310.1155/2023/6717854Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban UgandaClara Wekesa0Rosalind Parkes-Ratanshi1Gregory D. Kirk2Ponsiano Ocama3Infectious Diseases InstituteCambridge UniversityJohn Hopkins UniversityCollege of Health SciencesIntroduction. The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests. Methods. Among people living with and without HIV and attending care, we used the R ratio to evaluate for liver injury patterns. Liver injury patterns were defined as cholestatic (R<2), mixed (R=2‐5), and hepatocellular (R>5). Results. Overall, the proportions of participants with cholestatic liver injury, mixed liver injury, and hepatocellular liver injury were 55%, 34%, and 4%, respectively, with similar distribution when stratified by HIV status. Alcohol use among participants without HIV was associated with all patterns of liver injury (cholestatic liver injury (OR=4.9 CI (1.0-24.2); p=0.054), mixed liver injury (OR=5.3 CI (1.1-27.3); p=0.043), and hepatocellular liver injury (OR=13.2 CI (1.0-167.3); p=0.046)). Increasing age was associated with cholestatic liver injury among participants with HIV (OR=2.3 CI (1.0-5.3); p=0.038). Despite a high hepatitis B prevalence among participants with HIV, there was no association with liver injury. Conclusions. Liver injury is prevalent among both people living with and without HIV in care, and cholestatic liver injury is the most common pattern. Alcohol is associated with all patterns of liver injury and increasing age associated with cholestatic liver injury among people living without HIV and people living with HIV, respectively.http://dx.doi.org/10.1155/2023/6717854 |
| spellingShingle | Clara Wekesa Rosalind Parkes-Ratanshi Gregory D. Kirk Ponsiano Ocama Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda International Journal of Hepatology |
| title | Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda |
| title_full | Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda |
| title_fullStr | Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda |
| title_full_unstemmed | Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda |
| title_short | Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda |
| title_sort | liver injury patterns and hepatic toxicity among people living with and without hiv and attending care in urban uganda |
| url | http://dx.doi.org/10.1155/2023/6717854 |
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