Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study
Objective: We examined the prevalence and clinical characteristics of patients with major depressive disorder (MDD) without depressed mood, using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea. Methods: Using analysis of covariance for continuous variables and...
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| Format: | Article |
| Language: | English |
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AVES
2017-10-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
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| Online Access: | http://dx.doi.org/10.1080/24750573.2017.1367564 |
| _version_ | 1797907255781228544 |
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| author | Seon-Cheol Park Hong Seok Oh Jae-Min Kim Tae-Youn Jun Min-Soo Lee Jung-Bum Kim Hyeon-Woo Yim Yong Chon Park |
| author_facet | Seon-Cheol Park Hong Seok Oh Jae-Min Kim Tae-Youn Jun Min-Soo Lee Jung-Bum Kim Hyeon-Woo Yim Yong Chon Park |
| author_sort | Seon-Cheol Park |
| collection | DOAJ |
| description | Objective: We examined the prevalence and clinical characteristics of patients with major depressive disorder (MDD) without depressed mood, using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea. Methods: Using analysis of covariance for continuous variables and binary logistic regression analysis for discrete variables, the clinical characteristics of MDD patients with and without depressed mood were compared after controlling for the potential effects of gender. To represent the extent of group differences, we computed Cohen’s d statistics. Results: Of 1009 MDD patients, only 2.2% were without depressed mood. Compared with those with depressed mood, these patients were characterized by a significantly lower rate of current suicidal ideation (adjust odds ratio = 5.258, p = .003; d = 0.193), fewer depressive symptom profiles (F = 8.731, p = .003; d = −0.543) and lower severity scores for overall depression (F = 16.027, p < .0001; d = −0.853), core depressive symptoms (F = 14.233, p < .0001; d = −0.810), insomnia (F = 6.967, p = .008; d = −0.579), anxiety (F = 14.235, p < .0001; d = −0.810), and suicidal ideation (F = 9.034, p = .003; d = 0.531), as well as a higher level of social functioning (F = 6.862, p = .009; d = 0.531). Conclusions: MDD without depressed mood is associated with a lower illness burden than MDD with depressed mood, and may have the distinctive clinical characteristics of MDD. |
| first_indexed | 2024-04-10T10:33:33Z |
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| id | doaj.art-bb90816ddd9d4b0eb4a3c7bda891dac9 |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T10:33:33Z |
| publishDate | 2017-10-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-bb90816ddd9d4b0eb4a3c7bda891dac92023-02-15T16:20:59ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812017-10-0127443543810.1080/24750573.2017.13675641367564Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND studySeon-Cheol Park0Hong Seok Oh1Jae-Min Kim2Tae-Youn Jun3Min-Soo Lee4Jung-Bum Kim5Hyeon-Woo Yim6Yong Chon Park7Inje University College of Medicine and Haeundae Paik HospitalYong-In Mental HospitalChonnam National University School of MedicineCatholic University of KoreaKorea UniversityKeimyung University School of MedicineCatholic University of KoreaHanyang University Guri HospitalObjective: We examined the prevalence and clinical characteristics of patients with major depressive disorder (MDD) without depressed mood, using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea. Methods: Using analysis of covariance for continuous variables and binary logistic regression analysis for discrete variables, the clinical characteristics of MDD patients with and without depressed mood were compared after controlling for the potential effects of gender. To represent the extent of group differences, we computed Cohen’s d statistics. Results: Of 1009 MDD patients, only 2.2% were without depressed mood. Compared with those with depressed mood, these patients were characterized by a significantly lower rate of current suicidal ideation (adjust odds ratio = 5.258, p = .003; d = 0.193), fewer depressive symptom profiles (F = 8.731, p = .003; d = −0.543) and lower severity scores for overall depression (F = 16.027, p < .0001; d = −0.853), core depressive symptoms (F = 14.233, p < .0001; d = −0.810), insomnia (F = 6.967, p = .008; d = −0.579), anxiety (F = 14.235, p < .0001; d = −0.810), and suicidal ideation (F = 9.034, p = .003; d = 0.531), as well as a higher level of social functioning (F = 6.862, p = .009; d = 0.531). Conclusions: MDD without depressed mood is associated with a lower illness burden than MDD with depressed mood, and may have the distinctive clinical characteristics of MDD.http://dx.doi.org/10.1080/24750573.2017.1367564Anxietydepressed moodmajor depressive disordersuicidal ideationillness burden |
| spellingShingle | Seon-Cheol Park Hong Seok Oh Jae-Min Kim Tae-Youn Jun Min-Soo Lee Jung-Bum Kim Hyeon-Woo Yim Yong Chon Park Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study Psychiatry and Clinical Psychopharmacology Anxiety depressed mood major depressive disorder suicidal ideation illness burden |
| title | Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study |
| title_full | Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study |
| title_fullStr | Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study |
| title_full_unstemmed | Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study |
| title_short | Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: results from the CRESCEND study |
| title_sort | prevalence and clinical characteristics of major depressive disorder mdd without depressed mood in koreans with mdd results from the crescend study |
| topic | Anxiety depressed mood major depressive disorder suicidal ideation illness burden |
| url | http://dx.doi.org/10.1080/24750573.2017.1367564 |
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