<i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet
Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are generally added in considerable amounts to food as a food additive. Oral exposure to TiO<sub>2</sub> NPs could induce intestinal damage, especially in obese individuals with a high-fat diet. The probiotic <i>Bacil...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/21/3368 |
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| author | Qingying Shi Chen Yang Bingjie Zhang Dongxiao Chen Fuping Lu Huabing Zhao |
| author_facet | Qingying Shi Chen Yang Bingjie Zhang Dongxiao Chen Fuping Lu Huabing Zhao |
| author_sort | Qingying Shi |
| collection | DOAJ |
| description | Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are generally added in considerable amounts to food as a food additive. Oral exposure to TiO<sub>2</sub> NPs could induce intestinal damage, especially in obese individuals with a high-fat diet. The probiotic <i>Bacillus coagulans</i> (<i>B. coagulans</i>) exhibits good resistance in the gastrointestinal system and is beneficial to intestinal health. In this study, <i>B. coagulans</i> was used to treat intestinal damage caused by TiO<sub>2</sub> NPs in high-fat-diet mice via two intervention methods: administration of TiO<sub>2</sub> NPs and <i>B. coagulans</i> simultaneously and administration of TiO<sub>2</sub> NPs followed by that of <i>B. coagulans</i>. The intervention with <i>B. coagulans</i> was found to reduce the inflammatory response and oxidative stress. A 16S rDNA sequencing analysis revealed that <i>B. coagulans</i> had increased the diversity of gut microbiota and optimized the composition of gut microbiota. Fecal metabolomics analysis indicated that <i>B. coagulans</i> had restored the homeostasis of sphingolipids and amino acid metabolism. The intervention strategy of administering TiO<sub>2</sub> NPs followed by <i>B. coagulans</i> was found to be more effective. In conclusion, <i>B. coagulans</i> could alleviate intestinal damage induced by TiO<sub>2</sub> NPs in high-fat-diet mice TiO<sub>2</sub><i>B. coagulans</i>. Our results suggest a new avenue for interventions against intestinal damage induced by TiO<sub>2</sub> NPs. |
| first_indexed | 2024-03-09T19:05:46Z |
| format | Article |
| id | doaj.art-bb90ae51730247aa8f5567f6f3ddbcc1 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T19:05:46Z |
| publishDate | 2022-10-01 |
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| record_format | Article |
| series | Foods |
| spelling | doaj.art-bb90ae51730247aa8f5567f6f3ddbcc12023-11-24T04:39:41ZengMDPI AGFoods2304-81582022-10-011121336810.3390/foods11213368<i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat DietQingying Shi0Chen Yang1Bingjie Zhang2Dongxiao Chen3Fuping Lu4Huabing Zhao5College of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaTitanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are generally added in considerable amounts to food as a food additive. Oral exposure to TiO<sub>2</sub> NPs could induce intestinal damage, especially in obese individuals with a high-fat diet. The probiotic <i>Bacillus coagulans</i> (<i>B. coagulans</i>) exhibits good resistance in the gastrointestinal system and is beneficial to intestinal health. In this study, <i>B. coagulans</i> was used to treat intestinal damage caused by TiO<sub>2</sub> NPs in high-fat-diet mice via two intervention methods: administration of TiO<sub>2</sub> NPs and <i>B. coagulans</i> simultaneously and administration of TiO<sub>2</sub> NPs followed by that of <i>B. coagulans</i>. The intervention with <i>B. coagulans</i> was found to reduce the inflammatory response and oxidative stress. A 16S rDNA sequencing analysis revealed that <i>B. coagulans</i> had increased the diversity of gut microbiota and optimized the composition of gut microbiota. Fecal metabolomics analysis indicated that <i>B. coagulans</i> had restored the homeostasis of sphingolipids and amino acid metabolism. The intervention strategy of administering TiO<sub>2</sub> NPs followed by <i>B. coagulans</i> was found to be more effective. In conclusion, <i>B. coagulans</i> could alleviate intestinal damage induced by TiO<sub>2</sub> NPs in high-fat-diet mice TiO<sub>2</sub><i>B. coagulans</i>. Our results suggest a new avenue for interventions against intestinal damage induced by TiO<sub>2</sub> NPs.https://www.mdpi.com/2304-8158/11/21/3368TiO<sub>2</sub> NPs<i>Bacillus coagulans</i>intestinal microorganismsmetabolismhigh-fat diet |
| spellingShingle | Qingying Shi Chen Yang Bingjie Zhang Dongxiao Chen Fuping Lu Huabing Zhao <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet Foods TiO<sub>2</sub> NPs <i>Bacillus coagulans</i> intestinal microorganisms metabolism high-fat diet |
| title | <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet |
| title_full | <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet |
| title_fullStr | <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet |
| title_full_unstemmed | <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet |
| title_short | <i>Bacillus coagulans</i> Alleviates Intestinal Damage Induced by TiO<sub>2</sub> Nanoparticles in Mice on a High-Fat Diet |
| title_sort | i bacillus coagulans i alleviates intestinal damage induced by tio sub 2 sub nanoparticles in mice on a high fat diet |
| topic | TiO<sub>2</sub> NPs <i>Bacillus coagulans</i> intestinal microorganisms metabolism high-fat diet |
| url | https://www.mdpi.com/2304-8158/11/21/3368 |
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