In vivo CT imaging tracking of stem cells labeled with Au nanoparticles
Abstract Stem cell–based therapy offers great promise for a wide range of diseases and injuries that cannot be effectively treated by existing medicine and therapies. However, the translation of stem cell therapy to the clinic is still hampered by the lack of profound understanding about the surviva...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
|
| Series: | View |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/VIW.20200119 |
| _version_ | 1811253895325810688 |
|---|---|
| author | Jie Huang Hongying Bao Xiaodi Li Zhijun Zhang |
| author_facet | Jie Huang Hongying Bao Xiaodi Li Zhijun Zhang |
| author_sort | Jie Huang |
| collection | DOAJ |
| description | Abstract Stem cell–based therapy offers great promise for a wide range of diseases and injuries that cannot be effectively treated by existing medicine and therapies. However, the translation of stem cell therapy to the clinic is still hampered by the lack of profound understanding about the survival, differentiation, migration, homing, and fate of the transplanted stem cells during the therapy. To address these issues, computed tomography (CT) based on nanomaterials, in particular gold nanoparticles (AuNPs), has been developed for enhanced and long‐term imaging tracking of transplanted stem cells. In this Mini‐Review, we summarize the recent progress in AuNP‐based CT imaging tracking of stem cells, with focuses on new strategies to improve cellular uptake of AuNPs for better CT imaging contrast, and on multimodal imaging tracking of stem cells in vivo. Finally, we discuss the existing challenges and possible future developments of the AuNP‐based CT imaging tracking of stem cells for regenerative medicine and other biomedical applications. |
| first_indexed | 2024-04-12T16:58:46Z |
| format | Article |
| id | doaj.art-bb911c3a8709405a9f205f7b7f649cf6 |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-04-12T16:58:46Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-bb911c3a8709405a9f205f7b7f649cf62022-12-22T03:24:08ZengWileyView2688-39882688-268X2022-05-0133n/an/a10.1002/VIW.20200119In vivo CT imaging tracking of stem cells labeled with Au nanoparticlesJie Huang0Hongying Bao1Xiaodi Li2Zhijun Zhang3CAS Key Laboratory of Nano‐Bio Interface, Division of Nanobiomedicine Suzhou Institute of Nano‐Tech and Nano‐bionics, Chinese Academy of Sciences Suzhou ChinaCAS Key Laboratory of Nano‐Bio Interface, Division of Nanobiomedicine Suzhou Institute of Nano‐Tech and Nano‐bionics, Chinese Academy of Sciences Suzhou ChinaCAS Key Laboratory of Nano‐Bio Interface, Division of Nanobiomedicine Suzhou Institute of Nano‐Tech and Nano‐bionics, Chinese Academy of Sciences Suzhou ChinaCAS Key Laboratory of Nano‐Bio Interface, Division of Nanobiomedicine Suzhou Institute of Nano‐Tech and Nano‐bionics, Chinese Academy of Sciences Suzhou ChinaAbstract Stem cell–based therapy offers great promise for a wide range of diseases and injuries that cannot be effectively treated by existing medicine and therapies. However, the translation of stem cell therapy to the clinic is still hampered by the lack of profound understanding about the survival, differentiation, migration, homing, and fate of the transplanted stem cells during the therapy. To address these issues, computed tomography (CT) based on nanomaterials, in particular gold nanoparticles (AuNPs), has been developed for enhanced and long‐term imaging tracking of transplanted stem cells. In this Mini‐Review, we summarize the recent progress in AuNP‐based CT imaging tracking of stem cells, with focuses on new strategies to improve cellular uptake of AuNPs for better CT imaging contrast, and on multimodal imaging tracking of stem cells in vivo. Finally, we discuss the existing challenges and possible future developments of the AuNP‐based CT imaging tracking of stem cells for regenerative medicine and other biomedical applications.https://doi.org/10.1002/VIW.20200119computed tomographygold nanoparticlesimaginglabelingstem cellstracking |
| spellingShingle | Jie Huang Hongying Bao Xiaodi Li Zhijun Zhang In vivo CT imaging tracking of stem cells labeled with Au nanoparticles View computed tomography gold nanoparticles imaging labeling stem cells tracking |
| title | In vivo CT imaging tracking of stem cells labeled with Au nanoparticles |
| title_full | In vivo CT imaging tracking of stem cells labeled with Au nanoparticles |
| title_fullStr | In vivo CT imaging tracking of stem cells labeled with Au nanoparticles |
| title_full_unstemmed | In vivo CT imaging tracking of stem cells labeled with Au nanoparticles |
| title_short | In vivo CT imaging tracking of stem cells labeled with Au nanoparticles |
| title_sort | in vivo ct imaging tracking of stem cells labeled with au nanoparticles |
| topic | computed tomography gold nanoparticles imaging labeling stem cells tracking |
| url | https://doi.org/10.1002/VIW.20200119 |
| work_keys_str_mv | AT jiehuang invivoctimagingtrackingofstemcellslabeledwithaunanoparticles AT hongyingbao invivoctimagingtrackingofstemcellslabeledwithaunanoparticles AT xiaodili invivoctimagingtrackingofstemcellslabeledwithaunanoparticles AT zhijunzhang invivoctimagingtrackingofstemcellslabeledwithaunanoparticles |