Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review
Background: Health-related quality of life (HRQoL) has become an increasingly important patient-reported outcome in glioma studies. Ideally, collected HRQoL data should be exploited to the full, with proper analytical methods. This systematic review aimed to provide an overview on how HRQoL data is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/12/3502 |
| _version_ | 1797546865191813120 |
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| author | Marijke B. Coomans Marthe C.M. Peeters Johan A.F. Koekkoek Jan W. Schoones Jaap Reijneveld Martin J.B. Taphoorn Linda Dirven |
| author_facet | Marijke B. Coomans Marthe C.M. Peeters Johan A.F. Koekkoek Jan W. Schoones Jaap Reijneveld Martin J.B. Taphoorn Linda Dirven |
| author_sort | Marijke B. Coomans |
| collection | DOAJ |
| description | Background: Health-related quality of life (HRQoL) has become an increasingly important patient-reported outcome in glioma studies. Ideally, collected HRQoL data should be exploited to the full, with proper analytical methods. This systematic review aimed to provide an overview on how HRQoL data is currently evaluated in glioma studies, focusing on the research objectives and statistical analyses of HRQoL data. Methods: A systematic literature search in the databases PubMed, Embase, Web of Science and Cochrane was conducted up to 5 June 2020. Articles were selected based on predetermined inclusion criteria and information on study design, HRQoL instrument, HRQoL research objective and statistical methods were extracted. Results: A total of 170 articles describing 154 unique studies were eligible, in which 17 different HRQoL instruments were used. HRQoL was the primary outcome in 62% of the included articles, and 51% investigated ≥1 research question with respect to HRQoL, for which various analytical methods were used. In only 42% of the articles analyzing HRQoL results over time, the minimally clinical important difference was reported and interpreted. Eighty-six percent of articles reported HRQoL results at a group level only, and not at the individual patient level. Conclusion: Currently, the assessment and analysis of HRQoL outcomes in glioma studies is highly variable. Opportunities to maximize information obtained with HRQoL data include appropriate and complementary analyses at both the group and individual level, comprehensive reporting of HRQoL results in separate articles or supplementary material, and adherence to existing guidelines about the assessment, analysis and reporting of patient-reported outcomes. |
| first_indexed | 2024-03-10T14:36:13Z |
| format | Article |
| id | doaj.art-bb932d57a75344ff98980c64ab58cb06 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:36:13Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bb932d57a75344ff98980c64ab58cb062023-11-20T22:12:37ZengMDPI AGCancers2072-66942020-11-011212350210.3390/cancers12123502Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic ReviewMarijke B. Coomans0Marthe C.M. Peeters1Johan A.F. Koekkoek2Jan W. Schoones3Jaap Reijneveld4Martin J.B. Taphoorn5Linda Dirven6Department of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsWalaeus Library, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Neurology and Brain Tumour Center Amsterdam, Amsterdam University Medical Center, 1007 MB Amsterdam, The NetherlandsDepartment of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Neurology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsBackground: Health-related quality of life (HRQoL) has become an increasingly important patient-reported outcome in glioma studies. Ideally, collected HRQoL data should be exploited to the full, with proper analytical methods. This systematic review aimed to provide an overview on how HRQoL data is currently evaluated in glioma studies, focusing on the research objectives and statistical analyses of HRQoL data. Methods: A systematic literature search in the databases PubMed, Embase, Web of Science and Cochrane was conducted up to 5 June 2020. Articles were selected based on predetermined inclusion criteria and information on study design, HRQoL instrument, HRQoL research objective and statistical methods were extracted. Results: A total of 170 articles describing 154 unique studies were eligible, in which 17 different HRQoL instruments were used. HRQoL was the primary outcome in 62% of the included articles, and 51% investigated ≥1 research question with respect to HRQoL, for which various analytical methods were used. In only 42% of the articles analyzing HRQoL results over time, the minimally clinical important difference was reported and interpreted. Eighty-six percent of articles reported HRQoL results at a group level only, and not at the individual patient level. Conclusion: Currently, the assessment and analysis of HRQoL outcomes in glioma studies is highly variable. Opportunities to maximize information obtained with HRQoL data include appropriate and complementary analyses at both the group and individual level, comprehensive reporting of HRQoL results in separate articles or supplementary material, and adherence to existing guidelines about the assessment, analysis and reporting of patient-reported outcomes.https://www.mdpi.com/2072-6694/12/12/3502brain tumorquality of lifepatient-reported outcomequestionnaireHRQoLPRO |
| spellingShingle | Marijke B. Coomans Marthe C.M. Peeters Johan A.F. Koekkoek Jan W. Schoones Jaap Reijneveld Martin J.B. Taphoorn Linda Dirven Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review Cancers brain tumor quality of life patient-reported outcome questionnaire HRQoL PRO |
| title | Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review |
| title_full | Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review |
| title_fullStr | Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review |
| title_full_unstemmed | Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review |
| title_short | Research Objectives, Statistical Analyses and Interpretation of Health-Related Quality of Life Data in Glioma Research: A Systematic Review |
| title_sort | research objectives statistical analyses and interpretation of health related quality of life data in glioma research a systematic review |
| topic | brain tumor quality of life patient-reported outcome questionnaire HRQoL PRO |
| url | https://www.mdpi.com/2072-6694/12/12/3502 |
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