Roles for α-Synuclein in Gene Expression
α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein play...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/8/1166 |
| _version_ | 1797523791487696896 |
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| author | Mahalakshmi Somayaji Zina Lanseur Se Joon Choi David Sulzer Eugene V. Mosharov |
| author_facet | Mahalakshmi Somayaji Zina Lanseur Se Joon Choi David Sulzer Eugene V. Mosharov |
| author_sort | Mahalakshmi Somayaji |
| collection | DOAJ |
| description | α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity. |
| first_indexed | 2024-03-10T08:48:04Z |
| format | Article |
| id | doaj.art-bb96e3ae2caa4a2db26241b17d4e147a |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T08:48:04Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-bb96e3ae2caa4a2db26241b17d4e147a2023-11-22T07:45:28ZengMDPI AGGenes2073-44252021-07-01128116610.3390/genes12081166Roles for α-Synuclein in Gene ExpressionMahalakshmi Somayaji0Zina Lanseur1Se Joon Choi2David Sulzer3Eugene V. Mosharov4Departments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USADepartments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USADepartments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USADepartments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USADepartments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USAα-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity.https://www.mdpi.com/2073-4425/12/8/1166Parkinson’s diseaseα-Synucleingene expressionsignal transductionepigeneticssilencing therapeutics |
| spellingShingle | Mahalakshmi Somayaji Zina Lanseur Se Joon Choi David Sulzer Eugene V. Mosharov Roles for α-Synuclein in Gene Expression Genes Parkinson’s disease α-Synuclein gene expression signal transduction epigenetics silencing therapeutics |
| title | Roles for α-Synuclein in Gene Expression |
| title_full | Roles for α-Synuclein in Gene Expression |
| title_fullStr | Roles for α-Synuclein in Gene Expression |
| title_full_unstemmed | Roles for α-Synuclein in Gene Expression |
| title_short | Roles for α-Synuclein in Gene Expression |
| title_sort | roles for α synuclein in gene expression |
| topic | Parkinson’s disease α-Synuclein gene expression signal transduction epigenetics silencing therapeutics |
| url | https://www.mdpi.com/2073-4425/12/8/1166 |
| work_keys_str_mv | AT mahalakshmisomayaji rolesforasynucleiningeneexpression AT zinalanseur rolesforasynucleiningeneexpression AT sejoonchoi rolesforasynucleiningeneexpression AT davidsulzer rolesforasynucleiningeneexpression AT eugenevmosharov rolesforasynucleiningeneexpression |