Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease
Objective Consuming a low-iodine diet (LID) is a widely accepted practice before administering radioiodine (131I) to evaluate and to treat thyroid disease. Although this procedure is well established for the management of patients with differentiated thyroid cancer, its use in patients with benign...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2015-09-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000600501&lng=en&tlng=en |
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| author | Vanessa A. Santarosa Denise M. Orlandi Lia B. Fiorin Teresa S. Kasamatsu Gilberto K. Furuzawa Ilda S. Kunii Rosália P. Padovani Marília M. S. Marone Mário L. Castiglioni José Gilberto H Vieira Rui M. B. Maciel Magnus R. Dias-da-Silva João R. M. Martins |
| author_facet | Vanessa A. Santarosa Denise M. Orlandi Lia B. Fiorin Teresa S. Kasamatsu Gilberto K. Furuzawa Ilda S. Kunii Rosália P. Padovani Marília M. S. Marone Mário L. Castiglioni José Gilberto H Vieira Rui M. B. Maciel Magnus R. Dias-da-Silva João R. M. Martins |
| author_sort | Vanessa A. Santarosa |
| collection | DOAJ |
| description | Objective Consuming a low-iodine diet (LID) is a widely accepted practice before administering radioiodine (131I) to evaluate and to treat thyroid disease. Although this procedure is well established for the management of patients with differentiated thyroid cancer, its use in patients with benign disease is unclear. So, we aimed to evaluate the influence of a LID on the outcome in patients with Graves’ disease (GD) treated with131I. Subjects and methods We evaluated 67 patients with GD who were divided into 2 groups: one group (n = 31) consumed a LID for 1-2 weeks, and the second group (n = 36) was instructed to maintain a regular diet (RD). Results The LID group experienced a 23% decrease in urinary iodine after 1 week on the diet and a significant 42% decrease after 2 weeks on the diet. The majority (53%) of the patients in the LID group had urinary iodine levels that were consistent with deficient iodine intake. However, there was no difference in the rate of hyperthyroidism’s cure between the LID and the RD groups 6 months after 131I therapy. Furthermore, the therapeutic efficacy did not differ in patients with varying degrees of sufficient iodine intake (corresponding urinary iodine levels: < 10 μg/dL is deficient; 10-29.9 μg/dL is sufficient; and > 30 μg/dL is excessive). Conclusion In the present study, we demonstrated that although a LID decreased urinary iodine levels, those levels corresponding with sufficient or a mild excess in iodine intake did not compromise the therapeutic efficacy of131I for the treatment of GD. |
| first_indexed | 2024-04-12T01:10:18Z |
| format | Article |
| id | doaj.art-bb99c904bc8548bab2d66f9263facc1e |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-12T01:10:18Z |
| publishDate | 2015-09-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-bb99c904bc8548bab2d66f9263facc1e2022-12-22T03:54:07ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922015-09-0159650150610.1590/2359-3997000000082S2359-39972015000600501Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ diseaseVanessa A. SantarosaDenise M. OrlandiLia B. FiorinTeresa S. KasamatsuGilberto K. FuruzawaIlda S. KuniiRosália P. PadovaniMarília M. S. MaroneMário L. CastiglioniJosé Gilberto H VieiraRui M. B. MacielMagnus R. Dias-da-SilvaJoão R. M. MartinsObjective Consuming a low-iodine diet (LID) is a widely accepted practice before administering radioiodine (131I) to evaluate and to treat thyroid disease. Although this procedure is well established for the management of patients with differentiated thyroid cancer, its use in patients with benign disease is unclear. So, we aimed to evaluate the influence of a LID on the outcome in patients with Graves’ disease (GD) treated with131I. Subjects and methods We evaluated 67 patients with GD who were divided into 2 groups: one group (n = 31) consumed a LID for 1-2 weeks, and the second group (n = 36) was instructed to maintain a regular diet (RD). Results The LID group experienced a 23% decrease in urinary iodine after 1 week on the diet and a significant 42% decrease after 2 weeks on the diet. The majority (53%) of the patients in the LID group had urinary iodine levels that were consistent with deficient iodine intake. However, there was no difference in the rate of hyperthyroidism’s cure between the LID and the RD groups 6 months after 131I therapy. Furthermore, the therapeutic efficacy did not differ in patients with varying degrees of sufficient iodine intake (corresponding urinary iodine levels: < 10 μg/dL is deficient; 10-29.9 μg/dL is sufficient; and > 30 μg/dL is excessive). Conclusion In the present study, we demonstrated that although a LID decreased urinary iodine levels, those levels corresponding with sufficient or a mild excess in iodine intake did not compromise the therapeutic efficacy of131I for the treatment of GD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000600501&lng=en&tlng=enUrinary iodineiodine nutritional statusradioiodineGraves’ disease |
| spellingShingle | Vanessa A. Santarosa Denise M. Orlandi Lia B. Fiorin Teresa S. Kasamatsu Gilberto K. Furuzawa Ilda S. Kunii Rosália P. Padovani Marília M. S. Marone Mário L. Castiglioni José Gilberto H Vieira Rui M. B. Maciel Magnus R. Dias-da-Silva João R. M. Martins Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease Archives of Endocrinology and Metabolism Urinary iodine iodine nutritional status radioiodine Graves’ disease |
| title | Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease |
| title_full | Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease |
| title_fullStr | Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease |
| title_full_unstemmed | Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease |
| title_short | Low iodine diet does not improve the efficacy of radioiodine for the treatment of Graves’ disease |
| title_sort | low iodine diet does not improve the efficacy of radioiodine for the treatment of graves disease |
| topic | Urinary iodine iodine nutritional status radioiodine Graves’ disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000600501&lng=en&tlng=en |
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